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IN THIS ISSUE

Journal of the American College of Cardiology

October 23, 2012, Vol. 60, No. 17
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Inside This Issue

Inside This Issue
J Am Coll Cardiol. 2012;60(17):.
doi: 10.1016/S0735-1097(12)04809-7
TOPICS: #

State-of-the-art paper

Lessons From the Past and Promises for the Future for Carotid Intima-Media Thickness
Michiel L. Bots, MD, PhD; Kim Sutton-Tyrrell, DrPH
J Am Coll Cardiol. 2012;60(17):1599-1604.
doi: 10.1016/j.jacc.2011.12.061
TOPICS: atherosclerosis, cardiovascular disease risk factors, carotid intima-media thickness
Left Main Percutaneous Coronary Intervention
Paul S. Teirstein, MD; Matthew J. Price, MD
J Am Coll Cardiol. 2012;60(17):1605-1613.
doi: 10.1016/j.jacc.2012.01.085
TOPICS: percutaneous coronary intervention, coronary artery bypass surgery, left main coronary artery disease ...

Viewpoint

The Problem With Asymptomatic Cerebral Embolic Complications in Vascular Procedures: What If They Are Not Asymptomatic?
Daryl R. Gress, MD
J Am Coll Cardiol. 2012;60(17):1614-1616.
doi: 10.1016/j.jacc.2012.06.037
TOPICS: cerebral embolism, vascular surgical procedures

Clinical Research

Pre-procedural Risk Quantification for Carotid Stenting Using the CAS Score: A Report From the NCDR CARE Registry
Beau M. Hawkins, MD; Kevin F. Kennedy, MS; Jay Giri, MD, MPH; Adam J. Saltzman, MD; Kenneth Rosenfield, MD; Douglas E. Drachman, MD; Christopher J. White, MD; John A. Spertus, MD, MPH; Robert W. Yeh, MD, MSc
J Am Coll Cardiol. 2012;60(17):1617-1622.
doi: 10.1016/j.jacc.2012.07.026
TOPICS: atrial fibrillation, ischemic stroke, carotid stent, carotid angioplasty and stenting, national cardiovascular ...
Includes: Supplemental Content
Factors Contributing to the Lower Mortality With Ticagrelor Compared With Clopidogrel in Patients Undergoing Coronary Artery Bypass Surgery
Christoph Varenhorst, MD, PhD; Ulrica Alström, MD, PhD; Benjamin M. Scirica, MD, MPH; Charles W. Hogue, MD; Nils Åsenblad, Msc, PhLic; Robert F. Storey, MD; Ph. Gabriel Steg, MD; Jay Horrow, MD; Kenneth W. Mahaffey, MD; Richard C. Becker, MD; Stefan James, MD, PhD; Christopher P. Cannon, MD; Gunnar Brandrup-Wognsen, MD, PhD; Lars Wallentin, MD, PhD; Claes Held, MD, PhD
J Am Coll Cardiol. 2012;60(17):1623-1630.
doi: 10.1016/j.jacc.2012.07.021
TOPICS: clopidogrel, coronary artery bypass surgery, hemorrhage, infection, mortality, ticagrelor, study of platelet ...
Includes: Supplemental Content
A Diagnosis of the Metabolic Syndrome in Youth That Resolves by Adult Life Is Associated With a Normalization of High Carotid Intima-Media Thickness and Type 2 Diabetes Mellitus Risk: The Bogalusa Heart and Cardiovascular Risk in Young Finns Studies
Costan G. Magnussen, PhD; Juha Koskinen, MD, PhD; Markus Juonala, MD, PhD; Wei Chen, MD, PhD; Sathanur R. Srinivasan, PhD; Matthew A. Sabin, MD, PhD; Russell Thomson, PhD; Michael D. Schmidt, PhD; Quoc Manh Nguyen, MD, MPH; Ji-Hua Xu, MD, PhD; Michael R. Skilton, PhD; Mika Kähönen, MD, PhD; Tomi Laitinen, MD, PhD; Leena Taittonen, MD, PhD; Terho Lehtimäki, MD, PhD; Tapani Rönnemaa, MD, PhD; Jorma S.A. Viikari, MD, PhD; Gerald S. Berenson, MD; Olli T. Raitakari, MD, PhD
J Am Coll Cardiol. 2012;60(17):1631-1639.
doi: 10.1016/j.jacc.2012.05.056
TOPICS: metabolic syndrome x, cardiovascular disease risk factors, diabetes mellitus, type 2, carotid ...
Includes: Supplemental Content
The Population Burden of Heart Failure Attributable to Modifiable Risk Factors: The ARIC (Atherosclerosis Risk in Communities) Study
Christy L. Avery, PhD; Laura R. Loehr, MD, PhD; Christopher Baggett, PhD; Patricia P. Chang, MD, MPH; Anna M. Kucharska-Newton, PhD, MPH; Kunihiro Matsushita, MD, PhD; Wayne D. Rosamond, PhD; Gerardo Heiss, MD, PhD
J Am Coll Cardiol. 2012;60(17):1640-1646.
doi: 10.1016/j.jacc.2012.07.022
TOPICS: atherosclerosis, heart failure, atherosclerosis risk in communities
Prediction of Mortality in Clinical Practice for Medicare Patients Undergoing Defibrillator Implantation for Primary Prevention of Sudden Cardiac Death
Kenneth C. Bilchick, MD, MS; George J. Stukenborg, PhD, MA; Sandeep Kamath, MD; Alan Cheng, MD
J Am Coll Cardiol. 2012;60(17):1647-1655.
doi: 10.1016/j.jacc.2012.07.028
TOPICS: atrial fibrillation, primary prevention, sudden cardiac death, diabetes mellitus, implantable defibrillators, heart ...
Implantable Cardioverter-Defibrillators for Primary Prevention of Sudden Death: The Quest to Identify Patients Most Likely to Benefit⁎⁎ 
Alfred E. Buxton, MD
J Am Coll Cardiol. 2012;60(17):1656-1658.
doi: 10.1016/j.jacc.2012.06.041
TOPICS: primary prevention, sudden cardiac death, implantable defibrillators
Left Ventricular Midwall Fibrosis as a Predictor of Mortality and Morbidity After Cardiac Resynchronization Therapy in Patients With Nonischemic Cardiomyopathy
Francisco Leyva, MD; Robin J. Taylor; Paul W.X. Foley, MD; Fraz Umar, MD; Lawrence J. Mulligan, PhD; Kiran Patel, PhD; Berthold Stegemann, PhD; Tarek Haddad, MS; Russell E.A. Smith, MD; Sanjay K. Prasad, MD
J Am Coll Cardiol. 2012;60(17):1659-1667.
doi: 10.1016/j.jacc.2012.05.054
TOPICS: atrial fibrillation, left ventricular ejection fraction, heart failure, fibrosis, heart ventricle, morbidity, ...
Multimarker Strategy for Short-Term Risk Assessment in Patients With Dyspnea in the Emergency Department: The MARKED (Multi mARKer Emergency Dyspnea)-Risk Score
Luc W. Eurlings, MD; Sandra Sanders-van Wijk, MD; Roland van Kimmenade, MD, PhD; Aart Osinski, MD; Lidwien van Helmond, MD; Maud Vallinga, MD; Harry J. Crijns, MD, PhD; Marja P. van Dieijen-Visser, MD, PhD; Hans-Peter Brunner-La Rocca, MD, PhD; Yigal M. Pinto, MD, PhD
J Am Coll Cardiol. 2012;60(17):1668-1677.
doi: 10.1016/j.jacc.2012.06.040
TOPICS: dyspnea, biological markers, emergency service, hospital, risk assessment, c-reactive protein, amino-terminal pro-brain ...
Includes: Supplemental Content
Neuropeptide Y (NPY): Genetic Variation in the Human Promoter Alters Glucocorticoid Signaling, Yielding Increased NPY Secretion and Stress Responses
Kuixing Zhang, MD, PhD; Fangwen Rao, MD; Jose Pablo Miramontes-Gonzalez, MD, PhD; C. Makena Hightower, PhD; Brian Vaught, BS; Yuhong Chen, MD; Tiffany A. Greenwood, PhD; Andrew J. Schork, BS; Lei Wang, PhD; Manjula Mahata, PhD; Mats Stridsberg, PhD; Srikrishna Khandrika, PhD; Nilima Biswas, PhD; Maple M. Fung, MD; Jill Waalen, MD, MPH; Rita P. Middelberg, PhD; Andrew C. Heath, PhD; Grant W. Montgomery, PhD; Nicholas G. Martin, PhD; John B. Whitfield, PhD; Dewleen G. Baker, MD; Nicholas J. Schork, PhD; Caroline M. Nievergelt, PhD; Daniel T. O'Connor, MD
J Am Coll Cardiol. 2012;60(17):1678-1689.
doi: 10.1016/j.jacc.2012.06.042
TOPICS: signal transduction, stress response, glucocorticoids, neuropeptide y, genetics
Includes: Supplemental Content

Pre-Clinical Research

Detection of Antecedent Myocardial Ischemia With Multiselectin Molecular Imaging
Brian P. Davidson, MD; Beat A. Kaufmann, MD; J. Todd Belcik, BS, RCS, RDCS; Aris Xie, MS; Yue Qi, MD; Jonathan R. Lindner, MD
J Am Coll Cardiol. 2012;60(17):1690-1697.
doi: 10.1016/j.jacc.2012.07.027
TOPICS: ischemia, myocardial ischemia, e-selectin, p-selectin, selectins, diagnostic imaging, mice, molecular imaging, microbubbles ...
Includes: Supplemental Content
Antiarrhythmic Potential of Mesenchymal Stem Cell Is Modulated by Hypoxic Environment
Hye Jin Hwang, MD; Woochul Chang, PhD; Byeong-Wook Song, MS; Heesang Song, PhD; Min-Ji Cha, MS; Il-Kwon Kim, PhD; Soyeon Lim, PhD; Eun Ju Choi, BS; Onju Ham, BS; Se-Yeon Lee, BS; Jaemin Shim, MD; Boyoung Joung, MD, PhD; Hui-Nam Pak, MD, PhD; Sung Soon Kim, MD, PhD; Bum-Rak Choi, PhD; Yangsoo Jang, MD, PhD; Moon-Hyoung Lee, MD, PhD; Ki-Chul Hwang, PhD
J Am Coll Cardiol. 2012;60(17):1698-1706.
doi: 10.1016/j.jacc.2012.04.056
TOPICS: anti-arrhythmia agents, hypoxia, stem cell, mesenchymal
Includes: Supplemental Content
Taking the Cells Out of Cell Therapy⁎⁎ 
Eduardo Marbán, MD, PhD; Hee Cheol Cho, PhD; Eugenio Cingolani, MD
J Am Coll Cardiol. 2012;60(17):1707-1708.
doi: 10.1016/j.jacc.2012.05.053
TOPICS: stem cell therapy, cardiac regenerative therapy, cell therapy

Images in Cardiology

Apical Hypertrophic Cardiomyopathy With and Without Aneurysm
Arun Dahiya, MBBS; Paaladinesh Thavendiranathan, MD; James D. Thomas, MD; Scott D. Flamm, MD
J Am Coll Cardiol. 2012;60(17):1709-1709.
doi: 10.1016/j.jacc.2012.05.055
TOPICS: hypertrophic cardiomyopathy, aneurysm
Anomalous Origin of the Right Coronary Artery From the Pulmonary Artery With Reversal of Flow
Nicholas Y. Gallagher, BS; Valerian Fernandes, MD; Ullrich Ebersberger, MD; J. Reid Spears, BS; U. Joseph Schoepf, MD
J Am Coll Cardiol. 2012;60(17):e31-e31.
doi: 10.1016/j.jacc.2012.03.083
TOPICS: anomalous origin of coronary artery, pulmonary artery, right coronary artery, anomalous origin ...

Correspondence

Mechanical Valve Thrombosis With Dabigatran
Joel Price, MD, MPH; Mark Hynes, MD; Marino Labinaz, MD; Marc Ruel, MD, MPH; Munir Boodhwani, MD, MMSC
J Am Coll Cardiol. 2012;60(17):1710-1711.
doi: 10.1016/j.jacc.2012.06.039
TOPICS: #
18F-Fluoride Imaging for Atherosclerosis
Emile R. Mohler, MD; Abass Alavi, MD; Robert L. Wilensky, MD
J Am Coll Cardiol. 2012;60(17):1711-1712.
doi: 10.1016/j.jacc.2012.06.038
TOPICS: #
Reply
Marc R. Dweck, MD; Nikhil V. Joshi, MD; Nicholas A. Boon, MD; James H.F. Rudd, PhD; David E. Newby, DSc
J Am Coll Cardiol. 2012;60(17):1712-1713.
doi: 10.1016/j.jacc.2012.07.024
TOPICS: #
Efficiently Doing the Wrong Thing
Mark E. Dunlap, MD; Paul A. Sobotka, MD
J Am Coll Cardiol. 2012;60(17):1713-1713.
doi: 10.1016/j.jacc.2012.07.025
TOPICS: #
Reply
G. Michael Felker, MD, MHS; Robert J. Mentz, MD
J Am Coll Cardiol. 2012;60(17):1713-1714.
doi: 10.1016/j.jacc.2012.07.023
TOPICS: #
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