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ON THE COVER Noninvasive imaging of reporter genes after percutaneous delivery in swine. (Left) Percutaneous delivery system consisting of steerable guiding catheter (top), and a helical needle infusion catheter (middle). A steerable catheter provides maximum flexibility, allowing positioning of the catheter in virtually any area in the left ventricular (LV) cavity. The helical infusion catheter (middle) is "screwed" into the myocardium (bottom). The infusion catheter is used, first, to confirm the intramyocardial positioning of the catheter and then for the delivery of therapeutic material. (Middle) An LV angiogram is done for delineation of the LV endocardial contour (top). Intramyocardial positioning of the helical catheter is confirmed using contrast media (bottom), and gene therapy is then delivered. (Right) Positron emission tomography (PET)-computed tomography (CT) image of reporter gene activity 48 h after percutaneous gene delivery (top: PET; bottom: PET-CT), showing increased uptake of ¹⁸F-labeled 9-[4-fluoro-3-(hydroxymethyl)butyl]guanine (¹⁸F-FHBG, PET-tracer) in the myocardial areas where reporter genes were percutaneously delivered (anteroseptal myocardium, red circles). A = anterior; P = posterior; R = right; L = left. Images provided by Martin Rodriguez-Porcel, MD,*† Todd J. Brinton, MD,‡§ Ian Y. Chen, MSE,*§ Olivier Gheysens, MD,* Jennifer Lyons,‡ Fumiaki Ikeno, MD,‡ Jürgen K. Willman, MD,* Lily Wu, MD, PhD,|| Joseph C. Wu, MD, PhD,*‡ Alan C. Yeung, MD,‡ Paul Yock, MD,‡§ Sanjiv Sam Gambhir, MD, PhD,*§ from the *Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Division of Nuclear Medicine, Stanford University, Stanford, California; †Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota; Departments of ‡Cardiology and §Bioengineering, Stanford University, Stanford, California; and the ||Department of Urology, Jonsson Comprehensive Cancer Center, and Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California