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Legend. Histological sections of myocardial biopsy specimens (left) and immunoblotting (right) from a HF patient showing immunostaining for PCP (above) and PCPE (below). These molecules (brown) are located in interstitial and perivascular fibrosis (arrows), and in cardiomyocytes (arrowheads). PCP enzyme is responsible for extracellular generation of collagen type I, which is decreased by torasemide treatment (not shown), suggesting PCP to be a new target for antifibrotic strategies in HF. See pages 863 and 864.