EXPEDITED PUBLICATION
Diagnostic Performance of 64-Multidetector Row Coronary Computed Tomographic Angiography for Evaluation of Coronary Artery Stenosis in Individuals Without Known Coronary Artery DiseaseResults From the Prospective Multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) Trial
Matthew J. Budoff, MD*,*,
David Dowe, MD ,
James G. Jollis, MD ,
Michael Gitter, MD ,
John Sutherland, MD||,
Edward Halamert, MD¶,
Markus Scherer, MD#,
Raye Bellinger, MD**,
Arthur Martin, MD ,
Robert Benton, MD ,
Augustin Delago, MD and
James K. Min, MD
* Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, California
Department of Radiology, Atlantic Medical Imaging, Atlantic City, New Jersey
Department of Medicine, Duke University Medical Center, Durham, North Carolina
Appleton Cardiology, Appleton, Wisconsin
|| Arizona Heart Institute, Phoenix, Arizona
¶ Indiana Heart Hospital, Indianapolis, Indiana
# Northeast Medical Center, Concord, North Carolina
** Sacramento Heart and Vascular Research Center, Sacramento, California
 Southern Heart Center, Hattiesburg, Mississippi
 Capital Cardiology Associates, Albany, New York
 Departments of Medicine and Radiology, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York
Manuscript received May 13, 2008;
revised manuscript received July 11, 2008,
accepted July 30, 2008.
* Reprint requests and correspondence: Dr. Matthew J. Budoff, Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA, 1124 West Carson Street, Torrance, California (Email: mbudoff{at}labiomed.org).
Objectives: The purpose of this study was to evaluate the diagnostic accuracy of electrocardiographically gated 64-multidetector row coronary computed tomographic angiography (CCTA) in individuals without known coronary artery disease (CAD).
Background: CCTA is a promising method for detection and exclusion of obstructive coronary artery stenosis. To date, no prospective multicenter trial has evaluated the diagnostic accuracy of 64-multidetector row CCTA in populations with intermediate prevalence of CAD.
Methods: We prospectively evaluated subjects with chest pain at 16 sites who were clinically referred for invasive coronary angiography (ICA). CCTAs were scored by consensus of 3 independent blinded readers. The ICAs were evaluated for coronary stenosis based on quantitative coronary angiography (QCA). No subjects were excluded for baseline coronary artery calcium score or body mass index.
Results: A total of 230 subjects underwent both CCTA and ICA (59.1% male; mean age: 57 ± 10 years). On a patient-based model, the sensitivity, specificity, and positive and negative predictive values to detect 50% or 70% stenosis were 95%, 83%, 64%, and 99%, respectively, and 94%, 83%, 48%, 99%, respectively. No differences in sensitivity and specificity were noted for nonobese compared with obese subjects or for heart rates 65 beats/min compared with >65 beats/min, whereas calcium scores >400 reduced specificity significantly.
Conclusions: In this prospective multicenter trial of chest pain patients without known CAD, 64-multidetector row CCTA possesses high diagnostic accuracy for detection of obstructive coronary stenosis at both thresholds of 50% and 70% stenosis. Importantly, the 99% negative predictive value at the patient and vessel level establishes CCTA as an effective noninvasive alternative to ICA to rule out obstructive coronary artery stenosis. (A Study of Computed Tomography [CT] for Evaluation of Coronary Artery Blockages in Typical or Atypical Chest Pain; NCT00348569
[ClinicalTrials.gov]
)
Key Words: computed tomography coronary artery disease angiography
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Abbreviations and Acronyms
| | AUC = area under the receiver-operating characteristic curve | | CAC = coronary artery calcium | | CAD = coronary artery disease | | CCTA = coronary computed tomographic angiography | | ICA = invasive coronary angiography | | MDCT = multidetector (row) computed tomography | | NPV = negative predictive value | | PPV = positive predictive value | | QCA = quantitative coronary angiography |
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|
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|
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|
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|
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|
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|
 |
|

|
 |

|
 |
 
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|
 |
|

|
 |

|
 |
 
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|
 |
|

|
 |

|
 |
 
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[PDF]
|
 |
|

|
 |

|
 |
 
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58(19):
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[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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J. Am. Coll. Cardiol.,
November 1, 2011;
58(19):
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[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. M. LaBounty, J. Leipsic, R. Poulter, D. Wood, M. Johnson, M. B. Srichai, R. C. Cury, B. Heilbron, C. Hague, F. Y. Lin, et al.
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197(5):
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|
 |
|

|
 |

|
 |
 
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197(4):
829 - 837.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. K. Kumamaru, M. L. Steigner, S. Soga, J. Signorelli, A. Bedayat, K. Adams, D. Mitsouras, and F. J. Rybicki
Coronary Enhancement for Prospective ECG-Gated Single R-R Axial 320-MDCT Angiography: Comparison of 60- and 80-mL Iopamidol 370 Injection
Am. J. Roentgenol.,
October 1, 2011;
197(4):
844 - 850.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. S. Kim, K. S. Choo, D. W. Jeong, K. J. Chun, Y. H. Park, S. G. Song, J. H. Park, J. H. Kim, J. Kim, D. Han, et al.
Step-and-shoot prospectively ECG-gated vs. retrospectively ECG-gated with tube current modulation coronary CT angiography using 128-slice MDCT patients with chest pain: diagnostic performance and radiation dose
Acta Radiol,
October 1, 2011;
52(8):
860 - 865.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. L. Vavere, A. Arbab-Zadeh, C. E. Rochitte, M. Dewey, H. Niinuma, I. Gottlieb, M. E. Clouse, D. E. Bush, J. W. M. Hoe, A. de Roos, et al.
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October 1, 2011;
261(1):
100 - 108.
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|
 |
|

|
 |

|
 |
 
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J. Am. Coll. Cardiol.,
September 27, 2011;
58(14):
1414 - 1422.
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|
 |
|

|
 |

|
 |
 
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J. Am. Coll. Cardiol. Img.,
September 1, 2011;
4(9):
958 - 966.
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[PDF]
|
 |
|

|
 |

|
 |
 
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September 1, 2011;
32(17):
2100 - 2108.
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[PDF]
|
 |
|

|
 |

|
 |
 
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Circ Cardiovasc Imaging,
September 1, 2011;
4(5):
463 - 472.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Feuchtner, R. Goetti, A. Plass, M. Wieser, H. Scheffel, C. Wyss, P. Stolzmann, O. Donati, J. Schnabl, V. Falk, et al.
Adenosine Stress High-Pitch 128-Slice Dual-Source Myocardial Computed Tomography Perfusion for Imaging of Reversible Myocardial Ischemia: Comparison With Magnetic Resonance Imaging
Circ Cardiovasc Imaging,
September 1, 2011;
4(5):
540 - 549.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Nishio, Y. Ueda, K. Matsuo, M. Asai, T. Nemoto, A. Hirata, K. Kashiwase, and K. Kodama
Detection of disrupted plaques by coronary CT: comparison with angioscopy
Heart,
September 1, 2011;
97(17):
1397 - 1402.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. K. Min, A. Dunning, F. Y. Lin, S. Achenbach, M. Al-Mallah, M. J. Budoff, F. Cademartiri, T. Q. Callister, H.-J. Chang, V. Cheng, et al.
Age- and Sex-Related Differences in All-Cause Mortality Risk Based on Coronary Computed Tomography Angiography Findings: Results From the International Multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) of 23,854 Patients Without Known Coronary Artery Disease
J. Am. Coll. Cardiol.,
August 16, 2011;
58(8):
849 - 860.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Techasith and R. C. Cury
Stress Myocardial CT Perfusion: An Update and Future Perspective
J. Am. Coll. Cardiol. Img.,
August 1, 2011;
4(8):
905 - 916.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. J. Foley, M. F. McEntee, S. Achenbach, P. C. Brennan, L. S. Rainford, and J. D. Dodd
Breast Surface Radiation Dose During Coronary CT Angiography: Reduction by Breast Displacement and Lead Shielding
Am. J. Roentgenol.,
August 1, 2011;
197(2):
367 - 373.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Nasis, I. T. Meredith, N. Nerlekar, J. D. Cameron, P. R. Antonis, P. M. Mottram, M. C. Leung, J. M. Troupis, M. Crossett, A. G. Kambourakis, et al.
Acute Chest Pain Investigation: Utility of Cardiac CT Angiography in Guiding Troponin Measurement
Radiology,
August 1, 2011;
260(2):
381 - 389.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Nicol, J. Stirrup, A. Kelion, and S. Padley
Comparison with invasive coronary angiography
OSH Cardiovascular Computed Tomography,
August 1, 2011;
1(1):
med-9780199572595-div1-01 - med-9780199572595-div1-01.
[Full Text]
|
 |
|

|
 |

|
 |
 
F. Y. Lin, L. J. Shaw, A. M. Dunning, T. M. LaBounty, J.-H. Choi, J. W. Weinsaft, S. Koduru, M. J. Gomez, A. J. Delago, T. Q. Callister, et al.
Mortality Risk in Symptomatic Patients With Nonobstructive Coronary Artery Disease: A Prospective 2-Center Study of 2,583 Patients Undergoing 64-Detector Row Coronary Computed Tomographic Angiography
J. Am. Coll. Cardiol.,
July 26, 2011;
58(5):
510 - 519.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. F. d. Azevedo, M. S. Hadlich, S. G. Bezerra, J. L. Petriz, R. R. Alves, O. de Souza, M. Rati, D. C. Albuquerque, and J. Moll
Prognostic Value of CT Angiography in Patients With Inconclusive Functional Stress Tests
J. Am. Coll. Cardiol. Img.,
July 1, 2011;
4(7):
740 - 751.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Khan, F. Khosa, K. Nasir, A. Yassin, and M. E. Clouse
Comparison of Radiation Dose and Image Quality: 320-MDCT Versus 64-MDCT Coronary Angiography
Am. J. Roentgenol.,
July 1, 2011;
197(1):
163 - 168.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. Tamarappoo and R. Hachamovitch
Myocardial Perfusion Imaging Versus CT Coronary Angiography: When to Use Which?
J. Nucl. Med.,
July 1, 2011;
52(7):
1079 - 1086.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. J. Shaw and J. Narula
Coronary CT Angiography: An Established, Not Emerging, Basis of Diagnosis and Risk Stratification
J. Am. Coll. Cardiol. Img.,
May 1, 2011;
4(5):
565 - 566.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Fink, R. Krissak, T. Henzler, U. Lechel, G. Brix, R. A. P. Takx, J. W. Nance, J. A. Abro, S. O. Schoenberg, and U. J. Schoepf
Radiation Dose at Coronary CT Angiography: Second-Generation Dual-Source CT Versus Single-Source 64-MDCT and First-Generation Dual-Source CT
Am. J. Roentgenol.,
May 1, 2011;
196(5):
W550 - W557.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Nagata, S. Kato, K. Kitagawa, N. Ishida, H. Nakajima, S. Nakamori, M. Ishida, M. Miyahara, M. Ito, and H. Sakuma
Diagnostic Accuracy of 1.5-T Unenhanced Whole-Heart Coronary MR Angiography Performed with 32-Channel Cardiac Coils: Initial Single-Center Experience
Radiology,
May 1, 2011;
259(2):
384 - 392.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. C. Levin, L. Parker, E. J. Halpern, P. R. Julsrud, and V. M. Rao
The Lack of Growth in Use of Coronary CT Angiography: Is It Being Appropriately Used?
Am. J. Roentgenol.,
April 1, 2011;
196(4):
862 - 867.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. W. Kwon, Y. J. Kim, J. Shim, J. M. Sung, M. E. Han, D. W. Kang, J.-Y. Kim, B. W. Choi, and H.-J. Chang
Coronary Artery Calcium Scoring Does Not Add Prognostic Value to Standard 64-Section CT Angiography Protocol in Low-Risk Patients Suspected of Having Coronary Artery Disease
Radiology,
April 1, 2011;
259(1):
92 - 99.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. E. van Velzen, J. D. Schuijf, F. R. de Graaf, E. Boersma, G. Pundziute, F. Spano, M. J. Boogers, M. J. Schalij, L. J. Kroft, A. de Roos, et al.
Diagnostic performance of non-invasive multidetector computed tomography coronary angiography to detect coronary artery disease using different endpoints: detection of significant stenosis vs. detection of atherosclerosis
Eur. Heart J.,
March 1, 2011;
32(5):
637 - 645.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. D. Schuijf, S. Achenbach, P. J. de Feyter, and J. J. Bax
Current applications and limitations of coronary computed tomography angiography in stable coronary artery disease
Heart,
February 15, 2011;
97(4):
330 - 337.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Alfakih and M. Budoff
Multi-detector computed tomography coronary angiography: the incidental lung findings
J R Soc Med,
February 1, 2011;
104(2):
50 - 51.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Arbab-Zadeh and J. Hoe
Quantification of Coronary Arterial Stenoses by Multidetector CT Angiography in Comparison With Conventional Angiography: Methods, Caveats, and Implications
J. Am. Coll. Cardiol. Img.,
February 1, 2011;
4(2):
191 - 202.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. C. Cury, T. Techasith, G. Feuchtner, and G. Dabus
Cardiovascular Disease and Stroke in Women: Role of Radiology
Am. J. Roentgenol.,
February 1, 2011;
196(2):
265 - 273.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Khan, K. Nasir, F. Khosa, A. Saghir, S. Sarwar, and M. E. Clouse
Prospective Gating With 320-MDCT Angiography: Effect of Volume Scan Length on Radiation Dose
Am. J. Roentgenol.,
February 1, 2011;
196(2):
407 - 411.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Sakuma
Coronary CT versus MR Angiography: The Role of MR Angiography
Radiology,
February 1, 2011;
258(2):
340 - 349.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Catalan, R. Leta, A. Hidalgo, J. Montiel, X. Alomar, D. Vilades, A. Barros, S. Pujadas, F. Carreras, J. M. Padro, et al.
Ruling Out Coronary Artery Disease with Noninvasive Coronary Multidetector CT Angiography before Noncoronary Cardiovascular Surgery
Radiology,
February 1, 2011;
258(2):
426 - 434.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. M. M. Jenkins, N. Johnston, N. M. Hawkins, C.- M. Messow, J. Shand, K. J. Hogg, H. Eteiba, G. McKillop, N. E. R. Goodfield, A. McConnachie, et al.
Limited clinical utility of CT coronary angiography in a district hospital setting
QJM,
January 1, 2011;
104(1):
49 - 57.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Alfakih and M. Monaghan
Stress echocardiography in the age of multi-detector computed tomography
Eur Heart J Cardiovasc Imaging,
January 1, 2011;
12(1):
1 - 2.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Maffei, S. Seitun, C. Martini, A. Palumbo, G. Tarantini, E. Berti, R. Grilli, C. Tedeschi, G. Messalli, A. Guaricci, et al.
CT coronary angiography and exercise ECG in a population with chest pain and low-to-intermediate pre-test likelihood of coronary artery disease
Heart,
December 15, 2010;
96(24):
1973 - 1979.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. A. Mahabadi, S. Achenbach, C. Burgstahler, T. Dill, R. Fischbach, A. Knez, W. Moshage, B. M. Richartz, D. Ropers, S. Schroder, et al.
Safety, Efficacy, and Indications of {beta}-Adrenergic Receptor Blockade to Reduce Heart Rate prior to Coronary CT Angiography
Radiology,
December 1, 2010;
257(3):
614 - 623.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. E. van Velzen, J. D. Schuijf, L. J. Kroft, and J. J. Bax
Chapter 22 CT angiography and other applications of CT
The ESC Textbook of Acute and Intensive Cardiac Care,
December 1, 2010;
1(1):
med-9780199584314-chapter - med-9780199584314-chapter.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. K. Tamarappoo, D. Dey, R. Nakazato, H. Shmilovich, T. Smith, V. Y. Cheng, L. E. J. Thomson, S. W. Hayes, J. D. Friedman, G. Germano, et al.
Comparison of the Extent and Severity of Myocardial Perfusion Defects Measured by CT Coronary Angiography and SPECT Myocardial Perfusion Imaging
J. Am. Coll. Cardiol. Img.,
October 1, 2010;
3(10):
1010 - 1019.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Kato, K. Kitagawa, N. Ishida, M. Ishida, M. Nagata, Y. Ichikawa, K. Katahira, Y. Matsumoto, K. Seo, R. Ochiai, et al.
Assessment of Coronary Artery Disease Using Magnetic Resonance Coronary Angiography: A National Multicenter Trial
J. Am. Coll. Cardiol.,
September 14, 2010;
56(12):
983 - 991.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Nagel
Magnetic Resonance Coronary Angiography: The Condemned Live Longer
J. Am. Coll. Cardiol.,
September 14, 2010;
56(12):
992 - 994.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. P. Cormode, E. Roessl, A. Thran, T. Skajaa, R. E. Gordon, J.-P. Schlomka, V. Fuster, E. A. Fisher, W. J. M. Mulder, R. Proksa, et al.
Atherosclerotic Plaque Composition: Analysis with Multicolor CT and Targeted Gold Nanoparticles
Radiology,
September 1, 2010;
256(3):
774 - 782.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
I. Gottlieb, J. Brinker, J. A. C. Lima, and C. E. Rochitte
Reply.
J. Am. Coll. Cardiol.,
August 10, 2010;
56(7):
614 - 615.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K.-T. Ho, K.-C. Chua, E. Klotz, and C. Panknin
Stress and Rest Dynamic Myocardial Perfusion Imaging by Evaluation of Complete Time-Attenuation Curves With Dual-Source CT
J. Am. Coll. Cardiol. Img.,
August 1, 2010;
3(8):
811 - 820.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. R. de Graaf, J. D. Schuijf, J. E. van Velzen, L. J. Kroft, A. de Roos, J. H. C. Reiber, E. Boersma, M. J. Schalij, F. Spano, J. W. Jukema, et al.
Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease
Eur. Heart J.,
August 1, 2010;
31(15):
1908 - 1915.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. M. West and G. A. Beller
256- and 320-row coronary CTA: is more better?
Eur. Heart J.,
August 1, 2010;
31(15):
1823 - 1825.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Achenbach and W. G. Daniel
Cardiac imaging in the patient with chest pain: coronary CT angiography
Heart,
August 1, 2010;
96(15):
1241 - 1246.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Chua
The evolving role of molecular imaging for coronary artery disease: where do we stand today?
Heart Asia,
July 5, 2010;
1(1):
1 - 5.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. J. Shaw, J. K. Min, J. Narula, F. Lin, C. N. Bairey-Merz, T. Q. Callister, and D. S. Berman
Sex Differences in Mortality Associated With Computed Tomographic Angiographic Measurements of Obstructive and Nonobstructive Coronary Artery Disease: An Exploratory Analysis
Circ Cardiovasc Imaging,
July 1, 2010;
3(4):
473 - 481.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. K. Seneviratne, Q. A. Truong, F. Bamberg, I. S. Rogers, M. D. Shapiro, C. L. Schlett, C. U. Chae, R. Cury, S. Abbara, T. J. Brady, et al.
Incremental Diagnostic Value of Regional Left Ventricular Function Over Coronary Assessment by Cardiac Computed Tomography for the Detection of Acute Coronary Syndrome in Patients With Acute Chest Pain: From the ROMICAT Trial
Circ Cardiovasc Imaging,
July 1, 2010;
3(4):
375 - 383.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. B. Mark, D. S. Berman, M. J. Budoff, J. J. Carr, T. C. Gerber, H. S. Hecht, M. A. Hlatky, J. M. Hodgson, M. S. Lauer, J. M. Miller, et al.
ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 Expert Consensus Document on Coronary Computed Tomographic Angiography: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents
J. Am. Coll. Cardiol.,
June 8, 2010;
55(23):
2663 - 2699.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
WRITING COMMITTEE MEMBERS, D. B. Mark, D. S. Berman, M. J. Budoff, J. J. Carr, T. C. Gerber, H. S. Hecht, M. A. Hlatky, J. M. Hodgson, M. S. Lauer, et al.
ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 Expert Consensus Document on Coronary Computed Tomographic Angiography: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents
Circulation,
June 8, 2010;
121(22):
2509 - 2543.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Achenbach and P. Raggi
Imaging of coronary atherosclerosis by computed tomography
Eur. Heart J.,
June 2, 2010;
31(12):
1442 - 1448.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. M. LaBounty, R. J. Kim, F. Y. Lin, M. J. Budoff, J. W. Weinsaft, and J. K. Min
Diagnostic Accuracy of Coronary Computed Tomography Angiography as Interpreted on a Mobile Handheld Phone Device
J. Am. Coll. Cardiol. Img.,
May 1, 2010;
3(5):
482 - 490.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. J. Halpern, M. P. Savage, D. L. Fischman, and D. C. Levin
Cost-Effectiveness of Coronary CT Angiography in Evaluation of Patients Without Symptoms Who Have Positive Stress Test Results
Am. J. Roentgenol.,
May 1, 2010;
194(5):
1257 - 1262.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. Chenot, P. Montant, C. Goffinet, A. Pasquet, D. Vancraeynest, E. Coche, J. L. Vanoverschelde, and B. L. Gerber
Evaluation of Anatomic Valve Opening and Leaflet Morphology in Aortic Valve Bioprosthesis by Using Multidetector CT: Comparison with Transthoracic Echocardiography
Radiology,
May 1, 2010;
255(2):
377 - 385.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. K. Min, L. J. Shaw, and D. S. Berman
The Present State of Coronary Computed Tomography Angiography: A Process in Evolution
J. Am. Coll. Cardiol.,
March 9, 2010;
55(10):
957 - 965.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. K. Min, R. Hachamovitch, A. Rozanski, L. J. Shaw, D. S. Berman, and R. Gibbons
Clinical Benefits of Noninvasive Testing: Coronary Computed Tomography Angiography as a Test Case
J. Am. Coll. Cardiol. Img.,
March 1, 2010;
3(3):
305 - 315.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. K. Min, A. Gilmore, M. J. Budoff, D. S. Berman, and K. O'Day
Cost-effectiveness of Coronary CT Angiography versus Myocardial Perfusion SPECT for Evaluation of Patients with Chest Pain and No Known Coronary Artery Disease
Radiology,
March 1, 2010;
254(3):
801 - 808.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. J. Gibbons, P. A. Araoz, and E. E. Williamson
The Year in Cardiac Imaging
J. Am. Coll. Cardiol.,
February 2, 2010;
55(5):
483 - 495.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. A. Rocha-Filho, R. Blankstein, L. D. Shturman, H. G. Bezerra, D. R. Okada, I. S. Rogers, B. Ghoshhajra, U. Hoffmann, G. Feuchtner, W. S. Mamuya, et al.
Incremental Value of Adenosine-induced Stress Myocardial Perfusion Imaging with Dual-Source CT at Cardiac CT Angiography
Radiology,
February 1, 2010;
254(2):
410 - 419.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. G. J. Groothuis, A. M. Beek, S. L. Brinckman, M. R. Meijerink, S. C. Koestner, R. Nijveldt, M. J. W. Gotte, M. B. M. Hofman, C. van Kuijk, and A. C. van Rossum
Low to Intermediate Probability of Coronary Artery Disease: Comparison of Coronary CT Angiography with First-Pass MR Myocardial Perfusion Imaging
Radiology,
February 1, 2010;
254(2):
384 - 392.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. J. Wykrzykowska, A. Arbab-Zadeh, G. Godoy, J. M. Miller, S. Lin, A. Vavere, N. Paul, H. Niinuma, J. Hoe, J. Brinker, et al.
Assessment of In-Stent Restenosis Using 64-MDCT: Analysis of the CORE-64 Multicenter International Trial
Am. J. Roentgenol.,
January 1, 2010;
194(1):
85 - 92.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J E van Velzen, J D Schuijf, F R de Graaf, G Nucifora, G Pundziute, J W Jukema, M J Schalij, L J Kroft, A de Roos, J H C Reiber, et al.
Plaque type and composition as evaluated non-invasively by MSCT angiography and invasively by VH IVUS in relation to the degree of stenosis
Heart,
December 15, 2009;
95(24):
1990 - 1996.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. J. Shaw, R. Bugiardini, and C. N. B. Merz
Women and Ischemic Heart Disease: Evolving Knowledge
J. Am. Coll. Cardiol.,
October 20, 2009;
54(17):
1561 - 1575.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
O. Bruder, S. Schneider, D. Nothnagel, T. Dill, V. Hombach, J. Schulz-Menger, E. Nagel, M. Lombardi, A. C. van Rossum, A. Wagner, et al.
EuroCMR (European Cardiovascular Magnetic Resonance) Registry: Results of the German Pilot Phase
J. Am. Coll. Cardiol.,
October 6, 2009;
54(15):
1457 - 1466.
[Abstract]
[Full Text]
[PDF]
|
 |
|
|