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CLINICAL RESEARCH

Retinal Arteriolar Narrowing and Left Ventricular Remodeling

The Multi-Ethnic Study of Atherosclerosis

Ning Cheung, MBBS^_*,, David A. Bluemke, MD, PhD, Ronald Klein, MD, MPH, A. Richey Sharrett, MD, DrPH^||, F.M. Amirul Islam, PhD^_*, Mary Frances Cotch, PhD^¶, Barbara E.K. Klein, MD, MPH, Michael H. Criqui, MD, MPH^# and Tien Yin Wong, MD, PhD^_*,_**,_*

^_* Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
Royal Melbourne Hospital, Melbourne, Victoria, Australia
Departments of Radiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin
^|| Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
^¶ Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland
^# Department of Medicine, University of California San Diego, San Diego, California
^_** Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Manuscript received January 25, 2007; revised manuscript received March 2, 2007, accepted March 6, 2007.

^_* Reprint requests and correspondence: Dr. Tien Yin Wong, Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne 3002, Australia. (Email: twong{at}unimelb.edu.au).

Objectives: This study sought to examine the relationships of retinal vascular signs with left ventricular (LV) mass, volume, and concentric remodeling.

Background: Microvascular disease, reflected as retinopathy lesions, has been shown to predict clinical congestive heart failure. Whether these retinal vascular changes are related to early structural alterations and remodeling of the heart in asymptomatic individuals is unknown.

Methods: A cross-sectional, population-based study of 4,593 participants ages 45 to 85 years, free of clinical cardiovascular disease. Retinal vascular calibers and retinopathy were graded from retinal photographs according to standardized protocols. The LV mass and volume were measured from cardiac magnetic resonance imaging. Extent of LV concentric remodeling was determined by the ratio of LV mass to end-diastolic volume (M/V ratio).

Results: After controlling for age, gender, race, center, past and current systolic blood pressure, body mass index, smoking, antihypertensive medications, diabetes, diabetes duration, glycosylated hemoglobin, lipid profile, and C-reactive protein, narrower retinal arteriolar caliber was associated with concentric (highest quintile of M/V ratio) remodeling (odds ratio [OR] 2.06, 95% confidence interval 1.57 to 2.70). This association was seen in men and women, and was present even in those without diabetes, without hypertension, and without significant coronary calcification. In multivariate analysis, the presence of retinopathy (OR 1.31, 95% confidence interval 1.08 to 1.61) was also associated with concentric remodeling.

Conclusions: Narrower retinal arteriolar caliber is associated with LV concentric remodeling independent of traditional risk factors and coronary atherosclerotic burden, supporting the hypothesis that microvascular disease may contribute to cardiac remodeling.

Abbreviations and Acronyms   BMI = body mass index   BSA = body surface area   LV = left ventricle/ventricular   M/V ratio = mass to volume ratio   MRI = magnetic resonance imaging   OR = odds ratio   ROC = receiver-operator characteristic

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