CLINICAL RESEARCH
Amino-Terminal Pro-Brain Natriuretic Peptide, Renal Function, and Outcomes in Acute Heart Failure
Redefining the Cardiorenal Interaction?
Roland R.J. van Kimmenade, MD, PhD*,
James L. Januzzi, Jr, MD ,*,
Aaron L. Baggish, MD,
John G. Lainchbury, MD ,
Antoni Bayes-Genis, MD, PhD ,
A. Mark Richards, MD, PhD and
Yigal M. Pinto, MD, PhD*
* Department of Cardiology, University Hospital Maastricht, Maastricht, the Netherlands
Department of Cardiology, Massachusetts General Hospital, Boston, Massachusetts
Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Science, Christchurch, New Zealand
Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Manuscript received January 10, 2006;
revised manuscript received May 3, 2006,
accepted June 5, 2006.
* Reprint requests and correspondence: Dr. James L. Januzzi, Jr., Massachusetts General Hospital, Yawkey 5800, 55 Fruit Street, Boston, Massachusetts 02114. (Email: jjanuzzi{at}partners.org).
OBJECTIVES: We sought to study the individual and integrative role of amino-terminal pro-brain natriuretic peptide (NT-proBNP) and parameters of renal function for prognosis in heart failure.
BACKGROUND: Amino-terminal pro-BNP and renal impairment both predict death in patients with heart failure. Worsening of renal function in heart failure even defines the "cardiorenal syndrome."
METHODS: Seven hundred twenty subjects presenting with acute heart failure from 4 university-affiliated medical centers were dichotomized according to NT-proBNP concentration and baseline glomerular filtration rate. In addition, patients were divided according to changes in renal function. The primary end point was 60-day mortality.
RESULTS: The combination of a glomerular filtration rate (GFR) <60 ml/min/1.73 m2 with an NT-proBNP >4,647 pg/ml was the best predictor of 60-day mortality (odds ratio 3.46; 95% confidence interval 2.13 to 5.63). Among subjects with an NT-proBNP above the median, those with a GFR <60 ml/min/1.73 m2 or a creatinine rise  0.3 mg/dl had the worst prognosis, whereas in subjects with a NT-proBNP below the median, prognosis was not influenced by either impaired renal function at presentation or the development of renal impairment during admission.
CONCLUSIONS: The combination of NT-proBNP with measures of renal function better predicts short-term outcome in acute heart failure than either parameter alone. Among heart failure patients, the objective parameter of NT-proBNP seems more useful to delineate the "cardiorenal syndrome" than the previous criteria of a clinical diagnosis of heart failure.
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Abbreviations and Acronyms
| | BNP = brain natriuretic peptide | | GFR = glomerular filtration rate | | HF = heart failure | | ICON = International Collaborative on NT-proBNP | | MDRD = Modified Diet in Renal Disease | | NT-proBNP = amino-terminal pro-brain natriuretic peptide |
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