HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) View Abbreviations List All Versions of this Article: j.jacc.2006.05.063v1 48/9_Suppl_A/A47    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yan, S.-F. Articles by Schmidt, A. M. Search for Related Content PubMed Articles by Yan, S.-F. Articles by Schmidt, A. M.

STATE-OF-THE-ART PAPER

Protein Kinase C ß/Early Growth Response-1 Pathway

A Key Player in Ischemia, Atherosclerosis, and Restenosis

Department of Surgery, Columbia University, New York, New York

Manuscript received March 30, 2006; revised manuscript received May 24, 2006, accepted May 29, 2006.

^_* Reprint requests and correspondence: Dr. Shi-Fang Yan, Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, BB1705, New York, New York 10032. (Email: sy18{at}columbia.edu).

Atherosclerosis, restenosis, and the consequences of ischemia are the major causes of morbidity and mortality worldwide. Elucidation of key contributing pathways in animal models of ischemia-reperfusion injury, atherosclerosis, and restenosis consequent to vascular injury may lead to great interest in determining if blocking these pathways could prevent vascular disease in human subjects. This review details the evidence that the protein kinase C (PKC) ß/early growth response-1 axis plays a central role in the response to both acute and chronic vascular stresses in animal models and also indicates the clinical implications of a specific inhibitor of PKCß, ruboxistaurin (LY333531).

Abbreviations and Acronyms   apoE = apolipoprotein E   Egr-1 = early growth response-1   ERK1/2 = extracellular-signal-regulated protein kinase   JNK = c-Jun N-terminal kinase   OxLDL = oxidized low-density lipoprotein   PKC = protein kinase C

This article has been cited by other articles:

				S. Kobayashi, A. Ito, D. Okuzaki, H. Onda, N. Yabuta, I. Nagamori, K. Suzuki, H. Hashimoto, and H. Nojima Expression Profiling of PBMC-based Diagnostic Gene Markers Isolated from Vasculitis Patients DNA Res, June 17, 2008; (2008) dsn014v1. [Abstract] [Full Text] [PDF]