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CLINICAL RESEARCH: PEDIATRIC CARDIOLOGY

Heart Rate Response During Exercise Predicts Survival in Adults With Congenital Heart Disease

Gerhard-Paul Diller, MD^_*,, Konstantinos Dimopoulos, MD^_*, Darlington Okonko, BSc, MRCP, Anselm Uebing, MD^_*, Craig S. Broberg, MD^_*, Sonya Babu-Narayan, MRCP^_*, Stephanie Bayne, BSc^_*, Philip A. Poole-Wilson, MD, FRCP, Richard Sutton, DScMed, Darrel P. Francis, MA, MRCP and Michael A. Gatzoulis, MD, PhD^_*,_*

^_* Adult Congenital Heart Program, Department of Cardiology, Royal Brompton Hospital, London, United Kingdom
Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
Department of Pacing, Royal Brompton Hospital, London, United Kingdom
International Center for Circulatory Health, National Heart and Lung Institute, Imperial College, London, United Kingdom

Manuscript received January 23, 2006; revised manuscript received May 17, 2006, accepted May 22, 2006.

^_* Reprint requests and correspondence: Prof. Michael A. Gatzoulis, Adult Congenital Heart Program, Royal Brompton Hospital, Sydney Street, SW3 6NP London, United Kingdom (Email: m.gatzoulis{at}rbh.nthames.nhs.uk).

Presented as part of the 2005 Outstanding Research Award in Pediatric Cardiology at the American Heart Association Scientific Sessions, Dallas, Texas, November 13, 2005.

OBJECTIVES: To assess the prognostic value of heart rate response to exercise in adult congenital heart disease (ACHD) patients.

BACKGROUND: An abnormal heart rate response to exercise is related to autonomic dysfunction and may have prognostic implications in ACHD.

METHODS: We identified 727 consecutive ACHD patients (mean age [± SD] 33 ± 13 years) with varying diagnoses and without pacemakers. Peak oxygen consumption (peak VO₂), resting heart rate, and the increase in heart rate from resting level to peak exercise ("heart rate reserve") were measured. We also quantified the decrease in heart rate ("heart rate recovery") after cessation of exercise.

RESULTS: During a median follow-up of 28 months, 38 patients died. Lower values of heart rate reserve, peak heart rate, heart rate recovery, and peak VO₂ (p < 0.01 for each) were associated with increased mortality in univariate analysis. Furthermore, heart rate reserve predicted mortality independently of antiarrhythmic therapy, functional class, and peak VO₂. Stratifying patients by diagnostic groups revealed that a lower heart rate reserve was also associated with a greater risk of death in patients with complex anatomy, Fontan circulation, and tetralogy of Fallot (p < 0.05 for each).

CONCLUSIONS: An abnormal heart rate response to exercise identifies ACHD patients with a higher risk of mortality in the midterm, even after accounting for antiarrhythmic medication and exercise capacity. Heart rate reserve is a simple and inexpensive way to identify ACHD patients at higher mortality risk.

Abbreviations and Acronyms   ACHD = adult congenital heart disease   AUC = area under curve   NYHA = New York Heart Association   ROC = receiver-operating characteristic

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