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J Am Coll Cardiol, 2006; 48:227-235, doi:10.1016/j.jacc.2006.02.070 (Published online 22 June 2006).
© 2006 by the American College of Cardiology Foundation
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CARDIOVASCULAR GENOMIC MEDICINE

Gene Expression Analysis of Cardiovascular Diseases

Novel Insights Into Biology and Clinical Applications

David Seo, MD*, Geoffrey S. Ginsburg, MD, PhD and Pascal J. Goldschmidt-Clermont, MD

Division of Cardiology, Department of Medicine and Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina. Joshua Hare, MD, served as guest editor for this article.

Manuscript received October 19, 2005; revised manuscript received January 27, 2006, accepted February 8, 2006.

* Reprint requests and correspondence: Dr. David Seo, Duke University Medical Center, Box 3382, Durham, North Carolina 27710-0001 (Email: david.seo{at}duke.edu).

Although the contribution of genetics to complex cardiovascular diseases such as atherosclerosis has been accepted for quite some time, full and detailed knowledge of the individual causative genes has been elusive. With the advent of genomic technologies and methods, the necessary tools are now available to begin pinpointing the genes that contribute to disease susceptibility and progression. One approach being applied extensively in candidate gene discovery is gene expression analysis of human and animal tissues using microarrays. The genes identified by these genomic studies provide valuable insight into disease biology and represent the initial steps toward the development of diagnostic tests and therapeutic strategies that will substantially improve human health. This paper highlights the progress that has been made in using gene expression analysis cardiovascular genomic research and the potential for applying these findings in clinical medicine.

Abbreviations and Acronyms
  CARGO = Cardiac Allograft Rejection Gene Expression Observational study
  DNA = deoxyribonucleic acid
  ICM = ischemic cardiomyopathy
  LVAD = left ventricular assist device
  mRNA = messenger ribonucleic acid
  NF = nonfailing (myocardial samples)
  NICM = nonischemic cardiomyopathy
  PMBC = peripheral blood mononuclear cell
  QTL = quantitative trait locus
  SNP = single nucleotide polymorphism




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