JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 2006; 48:1-11, doi:10.1016/j.jacc.2006.02.056 (Published online 9 June 2006).
© 2006 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
j.jacc.2006.02.056v1
48/1/1    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jaffe, A. S.
Right arrow Articles by Apple, F. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jaffe, A. S.
Right arrow Articles by Apple, F. S.

STATE-OF-THE-ART PAPER

Biomarkers in Acute Cardiac Disease

The Present and the Future

Allan S. Jaffe, MD*,*, Luciano Babuin, MD* and Fred S. Apple, PhD{dagger}

* Division of Cardiovascular Diseases, Department of Medicine and the Department of Laboratory Medicine and Pathology, Mayo Clinic and Medical School, Rochester, Minnesota
{dagger} Hennepin County Medicine Center and the University of Minnesota School of Medicine, Department of Laboratory Medicine and Pathology, Minneapolis, Minnesota

Manuscript received July 8, 2005; revised manuscript received February 2, 2006, accepted February 16, 2006.

* Reprint requests and correspondence: Dr. Allan S. Jaffe, Cardiovascular Division, Gonda 5, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905 (Email: jaffe.allan{at}mayo.edu).

The use of biomarkers to aid diagnosis and treatment is increasing rapidly as genomics and proteomics help us expand the number of markers we can use and as an improved understanding of the pathophysiology of cardiac disease guides their use. However, as with all rapidly expanding fields, there is the risk of excessive enthusiasm unless we are circumspect about the data that guide the clinical use of these new tools. This review focuses first on how to use troponin, which at present is the best validated of the new markers, and will hopefully provide insight into how to use this biomarker more productively by distinguishing subsets of patients and by providing an understanding of the meaning of elevations in various clinical situations. The review then discusses the use as well as the knowledge gaps associated with emerging biomarkers such as B-type natriuretic peptide and C-reactive protein, which are increasingly moving toward more productive clinical use. Finally, it reflects on some of the large number of markers that are still in development.

Abbreviations and Acronyms
  ACS = acute coronary syndrome
  BNP = B-type natriuretic peptide
  CK = creatine kinase
  CRP = C-reactive protein
  cTn = cardiac troponin
  ECG = electrocardiogram
  ESRD = end-stage renal disease
  PCI = percutaneous coronary intervention




This article has been cited by other articles:


Home page
 CirculationHome page
R. A.H. Stewart, O. C. Raffel, A. J. Kerr, R. Gabriel, I. Zeng, A. A. Young, and B. R. Cowan
Pilot Study to Assess the Influence of {beta}-Blockade on Mitral Regurgitant Volume and Left Ventricular Work in Degenerative Mitral Valve Disease
Circulation, September 2, 2008; 118(10): 1041 - 1046.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. S. Jaffe
Key Issues in the Developing Synergism between Cardiovascular Imaging and Biomarkers
Clin. Chem., September 1, 2008; 54(9): 1432 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
C. J. Pepine
Provoked Coronary Spasm and Acute Coronary Syndromes
J. Am. Coll. Cardiol., August 12, 2008; 52(7): 528 - 530.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. E. Head and P. Barash
Progress Is Precarious
Anesth. Analg., August 1, 2008; 107(2): 362 - 364.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
O. M. Gutierrez, H. Tamez, I. Bhan, J. Zazra, M. Tonelli, M. Wolf, J. L. Januzzi, Y. Chang, and R. Thadhani
N-terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) Concentrations in Hemodialysis Patients: Prognostic Value of Baseline and Follow-up Measurements
Clin. Chem., August 1, 2008; 54(8): 1339 - 1348.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
B. A. Carabello
The Current Therapy for Mitral Regurgitation
J. Am. Coll. Cardiol., July 29, 2008; 52(5): 319 - 326.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
T Chung, W-C Lim, R Sy, I Cunningham, J Trotman, and L Kritharides
Subacute cardiac toxicity following autologous haematopoietic stem cell transplantation in patients with normal cardiac function
Heart, July 1, 2008; 94(7): 911 - 918.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
F. S. Apple, S. W. Smith, L. A. Pearce, R. Ler, and M. M. Murakami
Use of the Centaur TnI-Ultra Assay for Detection of Myocardial Infarction and Adverse Events in Patients Presenting With Symptoms Suggestive of Acute Coronary Syndrome
Clin. Chem., April 1, 2008; 54(4): 723 - 728.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
P. A Grayburn
How to measure severity of mitral regurgitation
Heart, March 1, 2008; 94(3): 376 - 383.
[Full Text] [PDF]

Home page
 HeartHome page
J Sanchis, X Bosch, V Bodi, N Bellera, J Nunez, B Benito, J Ordonez, L Consuegra, M Heras, and A Llecer
Combination of clinical risk profile, early exercise testing and circulating biomarkers for evaluation of patients with acute chest pain without ST-segment deviation or troponin elevation
Heart, March 1, 2008; 94(3): 311 - 315.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
U Ekelund and J L Forberg
New methods for improved evaluation of patients with suspected acute coronary syndrome in the emergency department
Postgrad. Med. J., February 1, 2008; 84(988): 83 - 86.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
L Stefani, G Galanti, L Toncelli, P Manetti, M C Vono, M Rizzo, and N Maffulli
Bicuspid aortic valve in competitive athletes
Br. J. Sports Med., January 1, 2008; 42(1): 31 - 35.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. M. Larson, K. M. Menssen, S. W. Sharkey, S. Duval, R. S. Schwartz, J. Harris, J. T. Meland, B. T. Unger, and T. D. Henry
"False-Positive" Cardiac Catheterization Laboratory Activation Among Patients With Suspected ST-Segment Elevation Myocardial Infarction
JAMA, December 19, 2007; 298(23): 2754 - 2760.
[Abstract] [Full Text] [PDF]

Home page
 Emerg. Med. J.Home page
U Ekelund and J L Forberg
New methods for improved evaluation of patients with suspected acute coronary syndrome in the emergency department
Emerg. Med. J., December 1, 2007; 24(12): 811 - 814.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. Thygesen, J. S. Alpert, H. D. White, and on behalf of the Joint ESC/ACCF/AHA/WHF Task Force
Universal Definition of Myocardial Infarction
J. Am. Coll. Cardiol., November 27, 2007; 50(22): 2173 - 2195.
[Full Text] [PDF]

Home page
 CirculationHome page
K. Thygesen, J. S. Alpert, H. D. White, on behalf of the Joint ESC/ACCF/AHA/WHF Task Force, TASK FORCE MEMBERS: Chairpersons: Kristian Thygese, Biomarker Group: Allan S. Jaffe, Coordinator (USA), ECG Group: Bernard Chaitman, Co-ordinator (USA), P, Imaging Group: Richard Underwood, Coordinator (UK), Intervention Group: Jean-Pierre Bassand, Co-ordina, Clinical Investigation Group: Paul W. Armstrong, C, et al.
Universal Definition of Myocardial Infarction
Circulation, November 27, 2007; 116(22): 2634 - 2653.
[Full Text] [PDF]

Home page
 Toxicol SciHome page
J. K. Dunnick, K. A. Thayer, and G. S. Travlos
Inclusion of Biomarkers for Detecting Perturbations in the Heart and Lung and Lipid/Carbohydrate Metabolism in National Toxicology Program Studies
Toxicol. Sci., November 1, 2007; 100(1): 29 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Task Force Members, K. Thygesen, J. S. Alpert, H. D. White, Biomarker Group, A. S. Jaffe, F. S. Apple, M. Galvani, H. A. Katus, L. K. Newby, et al.
Universal definition of myocardial infarction: Kristian Thygesen, Joseph S. Alpert and Harvey D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
Eur. Heart J., October 2, 2007; 28(20): 2525 - 2538.
[Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
E. M. Bhaskar
Management of Venous Thromboembolism
Ann Intern Med, October 2, 2007; 147(7): 519 - 520.
[Full Text] [PDF]

Home page
 Arch Intern MedHome page
F. Latif
Nonspecific Troponin Elevation
Arch Intern Med, September 24, 2007; 167(17): 1906 - 1907.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. L. Anderson, C. D. Adams, E. M. Antman, C. R. Bridges, R. M. Califf, D. E. Casey Jr, W. E. Chavey II, F. M. Fesmire, J. S. Hochman, T. N. Levin, et al.
ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
J. Am. Coll. Cardiol., August 14, 2007; 50(7): e1 - e157.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. L. Anderson, C. D. Adams, E. M. Antman, C. R. Bridges, R. M. Califf, D. E. Casey Jr, W. E. Chavey II, F. M. Fesmire, J. S. Hochman, T. N. Levin, et al.
ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
J. Am. Coll. Cardiol., August 14, 2007; 50(7): 652 - 726.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
F. S. Apple and M. M. Murakami
Serum and Plasma Cardiac Troponin I 99th Percentile Reference Values for 3 2nd-Generation Assays
Clin. Chem., August 1, 2007; 53(8): 1558 - 1560.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
B. T. Ivandic, E. Spanuth, D. Haase, H.-G. Lestin, and H. A. Katus
Increased Plasma Concentrations of Soluble CD40 Ligand in Acute Coronary Syndrome Depend on in Vitro Platelet Activation
Clin. Chem., July 1, 2007; 53(7): 1231 - 1234.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
F. di Marco, S. Grendene, G. Feltrin, D. Meneghetti, and G. Gerosa
Antiplatelet therapy in patients receiving aortic bioprostheses: A report of clinical and instrumental safety
J. Thorac. Cardiovasc. Surg., June 1, 2007; 133(6): 1597 - 1603.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
NACB Writing Group Members, F. S. Apple, R. L. Jesse, L. K. Newby, A. H.B. Wu, and R. H. Christenson
National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical Issues for Biochemical Markers of Acute Coronary Syndromes
Circulation, April 3, 2007; 115(13): e352 - e355.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
NACB WRITING GROUP MEMBERS, F. S. Apple, R. L. Jesse, L. K. Newby, A. H.B. Wu, R. H. Christenson, NACB COMMITTEE MEMBERS, R. H. Christenson, F. S. Apple, C. P. Cannon, et al.
National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical Issues for Biochemical Markers of Acute Coronary Syndromes
Clin. Chem., April 1, 2007; 53(4): 547 - 551.
[Full Text] [PDF]

Home page
 CirculationHome page
D. A. Morrow and J. A. de Lemos
Benchmarks for the Assessment of Novel Cardiovascular Biomarkers
Circulation, February 27, 2007; 115(8): 949 - 952.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
N. Nagajothi and A. Trivedi
Biomarkers in Acute Cardiac Disease
J. Am. Coll. Cardiol., December 5, 2006; 48(11): 2358 - 2358.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. S. Jaffe, L. Babuin, and F. S. Apple
Reply
J. Am. Coll. Cardiol., December 5, 2006; 48(11): 2358 - 2359.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W. B. Fye
Troponin Trumps Common Sense
J. Am. Coll. Cardiol., December 5, 2006; 48(11): 2357 - 2358.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. S. Jaffe
Chasing Troponin: How Low Can You Go if You Can See the Rise?
J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1763 - 1764.
[Full Text] [PDF]


HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 2006 by the American College of Cardiology Foundation.