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CLINICAL RESEARCH

Noninvasive Assessment of Plaque Morphology and Composition in Culprit and Stable Lesions in Acute Coronary Syndrome and Stable Lesions in Stable Angina by Multidetector Computed Tomography

Udo Hoffmann, MD^_*,_*, Fabian Moselewski, BS^_*,, Koen Nieman, MD^_*,, Ik-Kyung Jang, MD, PhD, Maros Ferencik, MD, PhD^_*, Ayaz M. Rahman, MD^_*, Ricardo C. Cury, MD^_*, Suhny Abbara, MD^_*, Hamid Joneidi-Jafari, BS^_*, Stephan Achenbach, MD^_*,, and Thomas J. Brady, MD^_*

^_* Department of Radiology
Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Department of Internal Medicine II, University of Erlangen, Erlangen, Germany

Manuscript received June 13, 2005; accepted November 9, 2005.

^_* Reprint requests and correspondence: Dr. Udo Hoffmann, Department of Radiology, Massachusetts General Hospital, 165 Charles River Plaza, Suite 400, Boston, Massachusetts 02114 (Email: uhoffmann{at}partners.org).

OBJECTIVES: The purpose of this study was to assess morphology and composition of culprit and stable coronary lesions by multidetector computed tomography (MDCT).

BACKGROUND: Noninvasive identification of culprit lesions has the potential to improve noninvasive risk stratification in patients with acute chest pain.

METHODS: Thirty-seven patients with acute coronary syndrome (ACS) or stable angina underwent coronary 16-slice MDCT and invasive selective angiography. In all significant coronary lesions two observers measured the degree of stenosis, plaque area at stenosis, and remodeling index and assessed plaque composition. Differences between culprit lesions in patients with ACS and stable lesions in patients with ACS or stable angina were determined.

RESULTS: We analyzed 40 lesions with excellent image quality in 14 patients with ACS and 9 patients with stable angina. Culprit lesions in patients with ACS (n = 14) had significantly greater plaque area and a higher remodeling index than both stable lesions in patients with ACS (n = 13) and in patients with stable angina (n = 13) (17.5 ± 5.9 mm² vs. 9.1 ± 4.8 mm² vs. 13.5 ± 10.7 mm², p = 0.02; and 1.4 ± 0.3 vs. 1.0 ± 0.4 vs. 1.2 ± 0.3, p = 0.04, respectively). The prevalence of non-calcified plaque was 100%, 62%, and 77%, respectively, and the prevalence of calcified plaque was 71%, 92%, and 85%, respectively, in culprit lesions in patients with ACS and in stable lesions in patients with ACS or stable angina.

CONCLUSIONS: We introduce the concept of noninvasive detection and characterization of coronary atherosclerotic lesions in patients with ACS by MDCT. We identified differences in lesion morphology and plaque composition between culprit lesions in ACS and stable lesions in ACS or stable angina, consistent with previous intravascular ultrasound studies.

Abbreviations and Acronyms   ACS = acute coronary syndrome   CT = computed tomography   ECG = electrocardiogram   HU = Hounsfield units   IVUS = intravascular ultrasound   LAD = left anterior descending (coronary artery)   LCX = left circumflex   LM = left main (coronary artery)   MDCT = multidetector computed tomography   NSTEMI = non–ST-segment elevation myocardial infarction   RCA = right coronary artery   RI = remodeling index

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