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CLINICAL RESEARCH

Endovascular Therapy for Chronic Mesenteric Ischemia

Jose A. Silva, MD, FACC^_*,_*, Christopher J. White, MD, FACC^_*, Tyrone J. Collins, MD, FACC^_*, J. Stephen Jenkins, MD, FACC^_*, Malcolm E. Andry, MD, John P. Reilly, MD, FACC^_* and Stephen R. Ramee, MD, FACC^_*

^_* Cardiology
Medicine, Section of Gastroenterology, Ochsner Clinic Foundation, New Orleans, Louisiana

Manuscript received July 20, 2005; revised manuscript received September 21, 2005, accepted October 3, 2005.

^_* Reprint requests and correspondence: Dr. Jose A. Silva, Department of Cardiology, Ochsner Clinic Foundation, Slidell Clinic, 2750 Gause Boulevard, Slidell, Louisiana 70461 (Email: jsilva{at}ochsner.org).

OBJECTIVES: We sought to describe the outcomes of a consecutive series of patients with chronic mesenteric ischemia (CMI) who were treated with percutaneous stent revascularization.

BACKGROUND: Historically, the treatment for CMI has been surgical revascularization. However, surgery carries a significant procedural complication rate and mortality.

METHODS: Fifty-nine consecutive patients with CMI underwent stent placement in 79 stenotic (>70%) mesenteric arteries. All patients had clinical follow-up and 90% had anatomical follow-up with angiography (computed tomography or conventional) or ultrasound at 6 months after the procedure.

RESULTS: Procedural success was obtained in 96% (76 of 79 arteries) and symptom relief occurred in 88% (50 patients). At a mean follow-up of 38 ± 15 months (range, 6 to 112 months), 79% of the patients remained alive, and 17% (n = 10) experienced a recurrence of symptoms. Angiography or ultrasound obtained at 14 ± 5 months after the procedure demonstrated a restenosis rate of 29% (n = 20). All patients with recurrent symptoms had angiographic in-stent restenosis and were successfully revascularized percutaneously.

CONCLUSIONS: Percutaneous stent placement for the treatment of CMI can be performed with a high procedural success and a low complication rate. The long-term freedom from symptoms and vascular patency are comparable with surgical results. The inherent lower procedural morbidity and mortality makes the endovascular approach the preferred revascularization technique for these patients.

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