HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: j.jacc.2005.07.069v1 47/2/301    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Toutouzas, K. Articles by Stefanadis, C. Search for Related Content PubMed PubMed Citation Articles by Toutouzas, K. Articles by Stefanadis, C.

CLINICAL RESEARCH: ACUTE CORONARY SYNDROMES

Elevated Plaque Temperature in Non-Culprit De Novo Atheromatous Lesions of Patients With Acute Coronary Syndromes

Hippokration Hospital, First Department of Cardiology, Athens Medical School, Athens, Greece

Manuscript received July 4, 2005; accepted July 20, 2005.

^_* Reprint requests and correspondence: Dr. Konstantinos Toutouzas, 24 Karaoli and Dimitriou str., 15562 Holargos, Athens, Greece (Email: ktoutouz{at}otenet.gr).

OBJECTIVES: We investigated whether there is increased temperature in non-culprit lesions, and the correlation of clinical syndrome with heat production of non-culprit lesions.

BACKGROUND: There is a controversy regarding whether there is widespread inflammation involving non-culprit lesions, or whether inflammatory involvement is limited to the culprit lesion. Coronary thermography assesses the local inflammatory involvement in atherosclerotic lesions.

METHODS: We included patients suffering from stable angina (SA) or acute coronary syndrome (ACS). All patients had two or more angiographically detectable lesions at different arteries. Culprit lesions should be identified in all patients. Patients with chronic total occlusions and multiple significant lesions at the culprit vessel were excluded. We measured at each non-culprit lesion the temperature difference (T) between the atherosclerotic plaque and the proximal vessel wall temperature.

RESULTS: The study population included 42 patients: 23 with SA, 19 with ACS. The T in non-culprit lesions was 0.08 ± 0.07°C. Patients with ACS had a higher temperature difference in non-culprit lesions compared with patients with SA (ACS 0.11 ± 0.08°C vs. SA 0.05 ± 0.06°C; p < 0.01). The mean value of T in non-culprit lesions was higher in the untreated group compared with the treated group with statins (0.11 ± 0.10°C vs. 0.06 ± 0.05°C; p = 0.05).

CONCLUSIONS: The results of this study show that heat is generated in non-culprit lesions. Moreover, in patients with ACS, temperature difference is increased compared with patients with stable angina.

Abbreviations and Acronyms   ACS = acute coronary syndrome   SA = stable angina   T = temperature difference

This article has been cited by other articles:

				T. J.L. Van De Parre, W. Martinet, S. Verheye, M. M. Kockx, G. Van Langenhove, A. G. Herman, and G. R.Y. De Meyer Mitochondrial uncoupling protein 2 mediates temperature heterogeneity in atherosclerotic plaques Cardiovasc Res, January 15, 2008; 77(2): 425 - 431. [Abstract] [Full Text] [PDF]

				S. Motoyama, T. Kondo, M. Sarai, A. Sugiura, H. Harigaya, T. Sato, K. Inoue, M. Okumura, J. Ishii, H. Anno, et al. Multislice Computed Tomographic Characteristics of Coronary Lesions in Acute Coronary Syndromes J. Am. Coll. Cardiol., July 24, 2007; 50(4): 319 - 326. [Abstract] [Full Text] [PDF]

				P. Schoenhagen Plaque Temperature, Arterial Remodeling, and Inflammation: Understanding "Hot-Spots" in the Coronary Arteries J. Am. Coll. Cardiol., June 12, 2007; 49(23): 2272 - 2273. [Full Text] [PDF]

				K. Toutouzas, A. Synetos, E. Stefanadi, S. Vaina, V. Markou, M. Vavuranakis, E. Tsiamis, D. Tousoulis, and C. Stefanadis Correlation Between Morphologic Characteristics and Local Temperature Differences in Culprit Lesions of Patients With Symptomatic Coronary Artery Disease J. Am. Coll. Cardiol., June 12, 2007; 49(23): 2264 - 2271. [Abstract] [Full Text] [PDF]