CLINICAL RESEARCH: PLATELETS AND STENT THROMBOSIS
Platelet Reactivity in Patients and Recurrent Events Post-Stenting
Results of the PREPARE POST-STENTING Study
Paul A. Gurbel, MD*,*,
Kevin P. Bliden, BS*,
Kirk Guyer, BS ,
Peter W. Cho, MD ,
Kazi A. Zaman, MD*,
Rolf P. Kreutz, MD*,
Ashwani K. Bassi, MD* and
Udaya S. Tantry, PhD*
* Sinai Center for Thrombosis Research, Baltimore, Maryland
Indiana University, Department of Chemistry, South Bend, Indiana
Department of Surgery, Sinai Hospital, Baltimore, Maryland
Manuscript received April 14, 2005;
revised manuscript received July 8, 2005,
accepted July 11, 2005.
* Reprint requests and correspondence: Dr. Paul A. Gurbel, Sinai Center for Thrombosis Research, Hoffberger Building, Suite 56, 2401 West Belvedere Avenue, Baltimore, Maryland 21215 (Email: pgurbel{at}lifebridgehealth.org).
OBJECTIVES: We investigated the relation of high ex vivo platelet reactivity, rapid fibrin generation, and high thrombin-induced clot strength to postdischarge ischemic events in patients undergoing percutaneous coronary intervention (PCI).
BACKGROUND: High platelet reactivity and rapid fibrin generation may affect the incidence of ischemic events after PCI. However, limited data is available to link these ex vivo markers to the occurrence of events.
METHODS: We measured platelet reactivity to adenosine diphosphate (ADP) by light transmittance aggregometry (LTA) in patients undergoing PCI (n = 192). Clot strength, a measure of thrombin-induced fibrin and platelet interactions, and the time to initial fibrin generation, a marker of thrombin activity, were measured by thrombelastography. The relation of these measurements to ischemic event occurrence was prospectively examined over six months.
RESULTS: A total of 100% and 84% of patients were on aspirin and clopidogrel therapy, respectively, at the time of the initial event. Posttreatment ADP-induced aggregation by LTA (63 ± 12% vs. 56 ± 15%, p = 0.02) and clot strength (MA) were higher (74 ± 5 mm vs. 65 ± 4 mm, p < 0.001) and time to initial fibrin generation was shorter (4.3 ± 1.3 min vs. 5.9 ± 1.5 min, p < 0.001) in patients with events (n = 38). The event rates in the highest quartiles of LTA and MA were 32% and 58%, respectively.
CONCLUSIONS: High platelet reactivity and clot strength, and rapid fibrin formation are novel risk factors for ischemic events after PCI. Clot strength is more predictive than ADP-induced platelet aggregation and may explain the occurrence of events despite treatment with cyclooxygenase-1 and P2Y12 inhibitors.
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Abbreviations and Acronyms
| | ADP = adenosine diphosphate | | GP = glycoprotein | | LTA = light transmittance aggregometry | | MA = clot strength | | PCI = percutaneous coronary intervention | | PPP = platelet-poor plasma | | PRP = platelet-rich plasma | | R = reaction time | | ROC = receiver operator curve | | TEG = thrombelastograph | | TVR = target vessel revascularization |
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|
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|
|
|
|
|
|
|
A. R. Shuldiner, J. R. O'Connell, K. P. Bliden, A. Gandhi, K. Ryan, R. B. Horenstein, C. M. Damcott, R. Pakyz, U. S. Tantry, Q. Gibson, et al.
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302(8):
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|
|
|
|
|
|
|
C. Verstuyft, T. Simon, and R. B. Kim
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[PDF]
|
|
|
|
|
|
|
L Bonello, A De Labriolle, M Scheinowitz, G Lemesle, P Roy, D H Steinberg, T L Pinto Slottow, R Pakala, A D Pichard, P Barragan, et al.
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95(15):
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|
|
|
|
|
|
|
A. D. Michelson, A. L. Frelinger III, E. Braunwald, W. E. Downey, D. J. Angiolillo, N. P. Xenopoulos, J. A. Jakubowski, Y. Li, S. A. Murphy, J. Qin, et al.
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30(14):
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|
|
|
|
|
|
|
N. B Norgard, K. D Mathews, and G. C Wall
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43(7):
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|
|
|
|
|
|
|
M. Valgimigli, G. Campo, N. de Cesare, E. Meliga, P. Vranckx, A. Furgieri, D. J. Angiolillo, M. Sabate, M. Hamon, A. Repetto, et al.
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|
|
|
|
|
|
|
M. J. Price
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119(19):
2625 - 2632.
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[PDF]
|
|
|
|
|
|
|
D. Tousoulis, A. Briasoulis, S. S Dhamrait, C. Antoniades, and C. Stefanadis
Effective platelet inhibition by aspirin and clopidogrel: where are we now?
Heart,
May 1, 2009;
95(10):
850 - 858.
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|
|
|
|
|
|
|
M. C. Wesley, F. X. McGowan, R. A. Castro, S. Dissanayake, D. Zurakowski, and J. A. DiNardo
The Effect of Milrinone on Platelet Activation as Determined by TEG(R) Platelet MappingTM
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May 1, 2009;
108(5):
1425 - 1429.
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|
|
|
|
|
|
|
N. R. Desai, J. L. Mega, S. Jiang, C. P. Cannon, and M. S. Sabatine
Interaction between cigarette smoking and clinical benefit of clopidogrel.
J. Am. Coll. Cardiol.,
April 14, 2009;
53(15):
1273 - 1278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Veverka and J. M. Hammer
Prasugrel: A New Thienopyridine Inhibitor
Journal of Pharmacy Practice,
April 1, 2009;
22(2):
158 - 165.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y. H. Jeong, S.-W. Lee, B.-R. Choi, I.-S. Kim, M.-K. Seo, C. H. Kwak, J.-Y. Hwang, and S.-W. Park
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J. Am. Coll. Cardiol.,
March 31, 2009;
53(13):
1101 - 1109.
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|
|
|
|
|
|
|
D. Sibbing, S. Braun, T. Morath, J. Mehilli, W. Vogt, A. Schomig, A. Kastrati, and N. von Beckerath
Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis.
J. Am. Coll. Cardiol.,
March 10, 2009;
53(10):
849 - 856.
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[PDF]
|
|
|
|
|
|
|
E. Mahla, M. J. Antonino, U. S. Tantry, and P. A. Gurbel
Point-of-care platelet function analysis ready for prime time?
J. Am. Coll. Cardiol.,
March 10, 2009;
53(10):
857 - 859.
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[PDF]
|
|
|
|
|
|
|
P. A. Gurbel, K. P. Bliden, J. F. Saucedo, T. A. Suarez, J. DiChiara, M. J. Antonino, E. Mahla, A. Singla, W. R. Herzog, A. K. Bassi, et al.
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J. Am. Coll. Cardiol.,
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53(8):
648 - 657.
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|
|
|
|
|
|
|
D. Erlinge, C. Varenhorst, O. O. Braun, S. James, K. J. Winters, J. A. Jakubowski, J. T. Brandt, A. Sugidachi, A. Siegbahn, and L. Wallentin
Patients With Poor Responsiveness to Thienopyridine Treatment or With Diabetes Have Lower Levels of Circulating Active Metabolite, but Their Platelets Respond Normally to Active Metabolite Added Ex Vivo
J. Am. Coll. Cardiol.,
December 9, 2008;
52(24):
1968 - 1977.
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|
|
|
|
|
|
|
I. Parastatidis, L. Thomson, A. Burke, I. Chernysh, C. Nagaswami, J. Visser, S. Stamer, D. C. Liebler, G. Koliakos, H. F. G. Heijnen, et al.
Fibrinogen {beta}-Chain Tyrosine Nitration Is a Prothrombotic Risk Factor
J. Biol. Chem.,
December 5, 2008;
283(49):
33846 - 33853.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
H. L. Dauerman
Coronary Intervention Without a Safety Net
J. Am. Coll. Cardiol.,
October 14, 2008;
52(16):
1299 - 1301.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Patti, A. Nusca, F. Mangiacapra, L. Gatto, A. D'Ambrosio, and G. Di Sciascio
Point-of-Care Measurement of Clopidogrel Responsiveness Predicts Clinical Outcome in Patients Undergoing Percutaneous Coronary Intervention: Results of the ARMYDA-PRO (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity Predicts Outcome) Study
J. Am. Coll. Cardiol.,
September 30, 2008;
52(14):
1128 - 1133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-P. Collet, J. Silvain, A. Landivier, M.-L. Tanguy, G. Cayla, A. Bellemain, N. Vignolles, S. Gallier, F. Beygui, A. Pena, et al.
Dose Effect of Clopidogrel Reloading in Patients Already on 75-mg Maintenance Dose: The Reload With Clopidogrel Before Coronary Angioplasty in Subjects Treated Long Term With Dual Antiplatelet Therapy (RELOAD) Study
Circulation,
September 16, 2008;
118(12):
1225 - 1233.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Gori, R. Marcucci, A. Migliorini, R. Valenti, G. Moschi, R. Paniccia, P. Buonamici, G. F. Gensini, R. Vergara, R. Abbate, et al.
Incidence and Clinical Impact of Dual Nonresponsiveness to Aspirin and Clopidogrel in Patients With Drug-Eluting Stents
J. Am. Coll. Cardiol.,
August 26, 2008;
52(9):
734 - 739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Trenk and F.-J. Neumann
Aspirin Resistance: An Underestimated Risk in Patients With Drug-Eluting Stents?
J. Am. Coll. Cardiol.,
August 26, 2008;
52(9):
740 - 742.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Guthikonda, C. L. Alviar, M. Vaduganathan, M. Arikan, A. Tellez, T. DeLao, J. F. Granada, J.-F. Dong, N. S. Kleiman, and E. I. Lev
Role of Reticulated Platelets and Platelet Size Heterogeneity on Platelet Activity After Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Patients With Stable Coronary Artery Disease
J. Am. Coll. Cardiol.,
August 26, 2008;
52(9):
743 - 749.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. P. Bliden, J. DiChiara, L. Lawal, A. Singla, M. J. Antonino, B. A. Baker, W. L. Bailey, U. S. Tantry, and P. A. Gurbel
The Association of Cigarette Smoking With Enhanced Platelet Inhibition by Clopidogrel
J. Am. Coll. Cardiol.,
August 12, 2008;
52(7):
531 - 533.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yano, T. Ohmori, S. Hoshide, S. Madoiwa, K. Yamamoto, T. Katsuki, T. Mitsuhashi, J. Mimuro, K. Shimada, K. Kario, et al.
Determinants of thrombin generation, fibrinolytic activity, and endothelial dysfunction in patients on dual antiplatelet therapy: involvement of factors other than platelet aggregability in Virchow's triad
Eur. Heart J.,
July 2, 2008;
29(14):
1729 - 1738.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. W. Kamphuisen
Thrombogenicity in patients with percutaneous coronary artery intervention and dual antiplatelet treatment
Eur. Heart J.,
July 2, 2008;
29(14):
1699 - 1700.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Geisler, M Kapp, K Gohring-Frischholz, K Daub, C Dosch, B Bigalke, H Langer, C Herdeg, and M Gawaz
Residual platelet activity is increased in clopidogrel- and ASA-treated patients with coronary stenting for acute coronary syndromes compared with stable coronary artery disease
Heart,
June 1, 2008;
94(6):
743 - 747.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Trenk, W. Hochholzer, M. F. Fromm, L.-E. Chialda, A. Pahl, C. M. Valina, C. Stratz, P. Schmiebusch, H.-P. Bestehorn, H. J. Buttner, et al.
Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents
J. Am. Coll. Cardiol.,
May 20, 2008;
51(20):
1925 - 1934.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Price, S. Endemann, R. R. Gollapudi, R. Valencia, C. T. Stinis, J. P. Levisay, A. Ernst, N. S. Sawhney, R. A. Schatz, and P. S. Teirstein
Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation
Eur. Heart J.,
April 2, 2008;
29(8):
992 - 1000.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Muller-Schunk, J. Linn, N. Peters, M. Spannagl, M. Deisenberg, H. Bruckmann, and T.E. Mayer
Monitoring of Clopidogrel-Related Platelet Inhibition: Correlation of Nonresponse with Clinical Outcome in Supra-Aortic Stenting
AJNR Am. J. Neuroradiol.,
April 1, 2008;
29(4):
786 - 791.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Kereiakes and P. A. Gurbel
Peri-Procedural Platelet Function and Platelet Inhibition in Percutaneous Coronary Intervention
J. Am. Coll. Cardiol. Intv.,
April 1, 2008;
1(2):
111 - 121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. L. L'Allier, G. Ducrocq, N. Pranno, S. Noble, R. Ibrahim, J. C. Gregoire, F. Azzari, A. Nozza, C. Berry, S. Doucet, et al.
Clopidogrel 600-mg double loading dose achieves stronger platelet inhibition than conventional regimens: results from the PREPAIR randomized study.
J. Am. Coll. Cardiol.,
March 18, 2008;
51(11):
1066 - 1072.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Prabhakaran, K.R Wells, V.H. Lee, C.A. Flaherty, and D.K. Lopes
Prevalence and Risk Factors for Aspirin and Clopidogrel Resistance in Cerebrovascular Stenting
AJNR Am. J. Neuroradiol.,
February 1, 2008;
29(2):
281 - 285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Wallentin, C. Varenhorst, S. James, D. Erlinge, O. O Braun, J. A. Jakubowski, A. Sugidachi, K. J. Winters, and A. Siegbahn
Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
Eur. Heart J.,
January 1, 2008;
29(1):
21 - 30.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Gurbel, R. C. Becker, K. G. Mann, S. R. Steinhubl, and A. D. Michelson
Platelet Function Monitoring in Patients With Coronary Artery Disease
J. Am. Coll. Cardiol.,
November 6, 2007;
50(19):
1822 - 1834.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Angiolillo, E. Bernardo, M. Sabate, P. Jimenez-Quevedo, M. A. Costa, J. Palazuelos, R. Hernandez-Antolin, R. Moreno, J. Escaned, F. Alfonso, et al.
Impact of Platelet Reactivity on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease
J. Am. Coll. Cardiol.,
October 16, 2007;
50(16):
1541 - 1547.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Campo, M. Valgimigli, D. Gemmati, G. Percoco, L. Catozzi, A. Frangione, F. Federici, F. Ferrari, M. Tebaldi, S. Luccarelli, et al.
Poor Responsiveness to Clopidogrel: Drug-Specific or Class-Effect Mechanism?: Evidence From a Clopidogrel-to-Ticlopidine Crossover Study
J. Am. Coll. Cardiol.,
September 18, 2007;
50(12):
1132 - 1137.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Schneider and B. E. Sobel
Conundrums in the Combined Use of Anticoagulants and Antiplatelet Drugs
Circulation,
July 17, 2007;
116(3):
305 - 315.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Gurbel, K. P. Bliden, J. DiChiara, J. Newcomer, W. Weng, N. K. Neerchal, T. Gesheff, S. K. Chaganti, A. Etherington, and U. S. Tantry
Evaluation of Dose-Related Effects of Aspirin on Platelet Function: Results From the Aspirin-Induced Platelet Effect (ASPECT) Study
Circulation,
June 26, 2007;
115(25):
3156 - 3164.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Buonamici, R. Marcucci, A. Migliorini, G. F. Gensini, A. Santini, R. Paniccia, G. Moschi, A. M. Gori, R. Abbate, and D. Antoniucci
Impact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis
J. Am. Coll. Cardiol.,
June 19, 2007;
49(24):
2312 - 2317.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Joshi, L. S. Magder, Z. Kon, S. Kallam, M. Kwon, R. Sangrampurkar, R. Pierson, and R. Poston
Association between prothrombin activation fragment (F1.2), cerebral ischemia (S-100{beta}) and international normalized ratio (INR) in patients with ventricular assisted devices
Interactive CardioVascular and Thoracic Surgery,
June 1, 2007;
6(3):
323 - 327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. O. Maree and D. J. Fitzgerald
Variable Platelet Response to Aspirin and Clopidogrel in Atherothrombotic Disease
Circulation,
April 24, 2007;
115(16):
2196 - 2207.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Angiolillo, A. Fernandez-Ortiz, E. Bernardo, F. Alfonso, C. Macaya, T. A. Bass, and M. A. Costa
Variability in Individual Responsiveness to Clopidogrel: Clinical Implications, Management, and Future Perspectives
J. Am. Coll. Cardiol.,
April 10, 2007;
49(14):
1505 - 1516.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gawaz and T. Geisler
Acute coronary syndromes, response to clopidogrel, and worsened cardiovascular outcomes: the hen and the egg dilemma: reply
Eur. Heart J.,
March 1, 2007;
28(5):
641 - 642.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. P. Bliden, J. DiChiara, U. S. Tantry, A. K. Bassi, S. K. Chaganti, and P. A. Gurbel
Increased Risk in Patients With High Platelet Aggregation Receiving Chronic Clopidogrel Therapy Undergoing Percutaneous Coronary Intervention: Is the Current Antiplatelet Therapy Adequate?
J. Am. Coll. Cardiol.,
February 13, 2007;
49(6):
657 - 666.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Angiolillo, S. B. Shoemaker, B. Desai, H. Yuan, R. K. Charlton, E. Bernardo, M. M. Zenni, L. A. Guzman, T. A. Bass, and M. A. Costa
Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease: Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study
Circulation,
February 13, 2007;
115(6):
708 - 716.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Geisler and M. Gawaz
Variability in response to clopidogrel: where is the threshold for 'low response'?: reply
Eur. Heart J.,
February 8, 2007;
(2007)
ehl500v1.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Geisler, N. Anders, M. Paterok, H. Langer, K. Stellos, S. Lindemann, C. Herdeg, A. E. May, and M. Gawaz
Platelet Response to Clopidogrel Is Attenuated in Diabetic Patients Undergoing Coronary Stent Implantation
Diabetes Care,
February 1, 2007;
30(2):
372 - 374.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Fitzgerald and A. Maree
Aspirin and Clopidogrel Resistance
Hematology,
January 1, 2007;
2007(1):
114 - 120.
[Abstract]
[Full Text]
[PDF]
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G. Campo, M. Valgimigli, D. Gemmati, G. Percoco, S. Tognazzo, G. Cicchitelli, L. Catozzi, P. Malagutti, M. Anselmi, C. Vassanelli, et al.
Value of Platelet Reactivity in Predicting Response to Treatment and Clinical Outcome in Patients Undergoing Primary Coronary Intervention: Insights Into the STRATEGY Study
J. Am. Coll. Cardiol.,
December 5, 2006;
48(11):
2178 - 2185.
[Abstract]
[Full Text]
[PDF]
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F. Alfonso and D. J. Angiolillo
Platelet Function Assessment to Predict Outcomes After Coronary Interventions: Hype or Hope?
J. Am. Coll. Cardiol.,
November 7, 2006;
48(9):
1751 - 1754.
[Full Text]
[PDF]
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J.P. Collet, Y. Allali, C. Lesty, M.L. Tanguy, J. Silvain, A. Ankri, B. Blanchet, R. Dumaine, J. Gianetti, L. Payot, et al.
Altered Fibrin Architecture Is Associated With Hypofibrinolysis and Premature Coronary Atherothrombosis
Arterioscler Thromb Vasc Biol,
November 1, 2006;
26(11):
2567 - 2573.
[Abstract]
[Full Text]
[PDF]
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T. Geisler, H. Langer, M. Wydymus, K. Gohring, C. Zurn, B. Bigalke, K. Stellos, A. E. May, and M. Gawaz
Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation
Eur. Heart J.,
October 2, 2006;
27(20):
2420 - 2425.
[Abstract]
[Full Text]
[PDF]
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D. J. Kereiakes and E. M. Antman
Clinical Guidelines and Practice: In Search of the Truth
J. Am. Coll. Cardiol.,
September 19, 2006;
48(6):
1129 - 1135.
[Abstract]
[Full Text]
[PDF]
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D. J. Angiolillo, A. Fernandez-Ortiz, E. Bernardo, C. Ramirez, U. Cavallari, E. Trabetti, M. Sabate, R. Hernandez, R. Moreno, J. Escaned, et al.
Contribution of Gene Sequence Variations of the Hepatic Cytochrome P450 3A4 Enzyme to Variability in Individual Responsiveness to Clopidogrel
Arterioscler Thromb Vasc Biol,
August 1, 2006;
26(8):
1895 - 1900.
[Abstract]
[Full Text]
[PDF]
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D. J. Angiolillo, E. Bernardo, C. Ramirez, M. A. Costa, M. Sabate, P. Jimenez-Quevedo, R. Hernandez, R. Moreno, J. Escaned, F. Alfonso, et al.
Insulin Therapy Is Associated With Platelet Dysfunction in Patients With Type 2 Diabetes Mellitus on Dual Oral Antiplatelet Treatment
J. Am. Coll. Cardiol.,
July 18, 2006;
48(2):
298 - 304.
[Abstract]
[Full Text]
[PDF]
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R. P. Giugliano and E. Braunwald
The Year in Non-ST-Segment Elevation Acute Coronary Syndromes
J. Am. Coll. Cardiol.,
July 18, 2006;
48(2):
386 - 395.
[Full Text]
[PDF]
|
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U. S. Tantry, K. P. Bliden, and P. A. Gurbel
Reply
J. Am. Coll. Cardiol.,
June 20, 2006;
47(12):
2566 - 2566.
[Full Text]
[PDF]
|
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S. R. Dixon, C. L. Grines, and W. W. O'Neill
The Year in Interventional Cardiology
J. Am. Coll. Cardiol.,
April 18, 2006;
47(8):
1689 - 1706.
[Full Text]
[PDF]
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D. J. Angiolillo, A. Fernandez-Ortiz, E. Bernardo, C. Ramirez, M. Sabate, P. Jimenez-Quevedo, R. Hernandez, R. Moreno, J. Escaned, F. Alfonso, et al.
Clopidogrel Withdrawal Is Associated With Proinflammatory and Prothrombotic Effects in Patients With Diabetes and Coronary Artery Disease
Diabetes,
March 1, 2006;
55(3):
780 - 784.
[Abstract]
[Full Text]
[PDF]
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Post-Stenting Antiplatelet Therapy: Further Insights
Journal Watch Cardiology,
December 16, 2005;
2005(1216):
4 - 4.
[Full Text]
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