HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: j.jacc.2006.10.078v1 49/18/1874    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Silva, M. C. Articles by Rochitte, C. E. Search for Related Content PubMed Articles by Silva, M. C. Articles by Rochitte, C. E.

CLINICAL RESEARCH: CARDIAC IMAGING

Myocardial Delayed Enhancement by Magnetic Resonance Imaging in Patients With Muscular Dystrophy

Marly Conceição Silva, MD^_*, Zilda Maria Alves Meira, MD, PhD, Juliana Gurgel Giannetti, MD, PhD, Marcelo Moreira da Silva, Alysson Félix Oliveira Campos, RT^_*, Márcia de Melo Barbosa, MD, PhD^_*, Geraldo Moll Starling Filho, MD^_*, Rogério de Aguiar Ferreira, MD^_*, Mayana Zatz, PhD and Carlos Eduardo Rochitte, MD, PhD^_*,,_*

^_* Axial Centro de Imagem, Belo Horizonte, Minas Gerais, Brazil
Federal University of Minas Gerais Medical School, Minas Gerais, Brazil
Human Genome Research Center, Biosciences Institute, University of São Paulo, São Paulo, Brazil
Heart Institute (InCor) University of São Paulo Medical School, São Paulo, Brazil.

Manuscript received May 22, 2006; revised manuscript received September 21, 2006, accepted October 16, 2006.

^_* Reprint requests and correspondence: Dr. Carlos E. Rochitte, Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Setor de Ressonância Magnética e Tomografia Cardiovascular, Avenida Dr. Enéas de Carvalho Aguiar, 44, Andar AB, Cerqueira César, São Paulo, SP, Brazil 05403-000. (Email: rochitte{at}incor.usp).

Objectives: This study sought to analyze whether cardiovascular magnetic resonance (CMR) can detect and quantify myocardial damage in the early stages of cardiomyopathy in muscular dystrophies (MD).

Background: Muscular dystrophy is a genetic disease that involves skeletal and cardiac tissues of humans. Cardiomyopathy is common, and death secondary to cardiac or respiratory diseases occurs early in life. Cardiovascular magnetic resonance is a reliable method for assessing global and regional cardiac function, allowing also for the detection of myocardial fibrosis (MF).

Methods: Ten patients with Duchenne or Becker dystrophies were studied by CMR. Physical examination, Chagas disease serological tests, electrocardiogram, chest radiograph, total creatine kinase, and Doppler echocardiogram were also obtained in all patients.

Results: Patients with MF had a lower ejection fraction than those without. Myocardial fibrosis (midwall and/or subepicardial) was observed in 7 of the 10 patients, and the lateral wall was the most commonly involved segment. There was moderate correlation between segmental MF and dysfunction.

Conclusions: Cardiovascular magnetic resonance can identify MF and may be useful for detecting the early stages of cardiomyopathy in MD. Future work will be needed to evaluate whether CMR can influence cardiomyopathy and outcomes.

Abbreviations and Acronyms   CK = creatine kinase   CMR = cardiovascular magnetic resonance   LV = left ventricle/ventricular   LVEF = left ventricular ejection fraction   MD = muscular dystrophy   MDE = myocardial delayed enhancement   MF = myocardial fibrosis   RV = right ventricle/ventricular

This article has been cited by other articles:

				W P Bandettini and A E Arai Advances in clinical applications of cardiovascular magnetic resonance imaging Heart, November 1, 2008; 94(11): 1485 - 1495. [Abstract] [Full Text] [PDF]

				E. M McNally Duchenne muscular dystrophy: how bad is the heart? Heart, August 1, 2008; 94(8): 976 - 977. [Full Text] [PDF]

				V. Giglio, G. Camastra, and G. Ansalone Myocardial Late Enhancement in Duchenne and Becker Individuals in the Clinical Milieu J. Am. Coll. Cardiol., November 13, 2007; 50(20): 2019 - 2020. [Full Text] [PDF]

				M. C. Silva, Z. M. A. Meira, J. Gurgel Giannetti, M. Zatz, and C. E. Rochitte Reply J. Am. Coll. Cardiol., November 13, 2007; 50(20): 2020 - 2020. [Full Text] [PDF]