CLINICAL RESEARCH: CARDIAC IMAGING
Pre-Operative Computed Tomography Coronary Angiography to Detect Significant Coronary Artery Disease in Patients Referred for Cardiac Valve Surgery
Willem B. Meijboom, MD*, ,
Nico R. Mollet, MD, PhD*,,
Carlos A.G. Van Mieghem, MD*,,
Jolanda Kluin, MD, PhD ,
Annick C. Weustink, MD*,,
Francesca Pugliese, MD*,,
Eleni Vourvouri, MD, PhD*,,
Filippo Cademartiri, MD, PhD*,,
Ad J.J.C. Bogers, MD, PhD,
Gabriel P. Krestin, MD, PhD and
Pim J. de Feyter, MD, PhD, FACC*,,*
* Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Radiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Cardiothoracic Surgery, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands.
Manuscript received March 21, 2006;
revised manuscript received June 6, 2006,
accepted June 19, 2006.
* Reprint requests and correspondence: Dr. Pim J. de Feyter, Erasmus Medical Center Department of Cardiology and Radiology, Thoraxcenter, Room Ba 589, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands. (Email: p.j.defeyter{at}erasmusmc.nl).
OBJECTIVES: We studied the diagnostic performance of 64-slice computed tomography coronary angiography (CTCA) to rule out or detect significant coronary stenosis in patients referred for valve surgery.
BACKGROUND: Invasive conventional coronary angiography (CCA) is recommended in most patients scheduled for valve surgery.
METHODS: During a 6-month period, 145 patients were prospectively identified from a consecutive patient population scheduled for valve surgery. Thirty-five patients were excluded because of CTCA criteria: irregular heart rhythm (n = 26), impaired renal function (n = 5), and known contrast allergy (n = 4). General exclusion criteria were: hospitalization in community hospital (n = 4), no need for CCA (n = 4), previous coronary artery bypass surgery (n = 1), or percutaneous coronary intervention (n = 4). Of the remaining 97 patients, 27 denied written informed consent. Thus, the study population comprised 70 patients (49 male, 21 female; mean age 63 ± 11 years).
RESULTS: Prevalence of significant coronary artery disease, defined as having at least 1  50% stenosis per patient, was 25.7%. Beta-blockers were administered in 71%, and 64% received lorazepam. The mean heart rate dropped from 72.5 ± 12.4 to 59.5 ± 7.5 beats/min. The mean scan time was 12.8 ± 1.3 s. On a per-patient analysis, the sensitivity, specificity, and positive and negative predictive values were: 100% (18 of 18; 95% confidence interval [CI] 78 to 100), 92% (48 of 52; 95% CI 81 to 98), 82% (18 of 22; 95% CI 59 to 94), and 100% (48 of 48; 95% CI 91 to 100), respectively.
CONCLUSIONS: The diagnostic accuracy of 64-slice CTCA for ruling out the presence of significant coronary stenoses in patients undergoing valve surgery is excellent and allows CTCA implementation as a gatekeeper for invasive CCA in these patients.
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Abbreviations and Acronyms
| | AHA = American Heart Association | | CAD = coronary artery disease | | CCA = conventional coronary angiogram | | CT = computed tomography | | CTCA = computed tomography coronary angiogram | | ECG = electrocardiographic | | LAD = left anterior descending coronary artery | | LVF = left ventricular function | | QCA = quantitative coronary angiography | | RCA = right coronary artery |
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