CLINICAL RESEARCH: CARDIAC IMAGING
Traditional Cardiovascular Risk Factors in Relation to Left Ventricular Mass, Volume, and Systolic Function by Cardiac Magnetic Resonance Imaging
The Multiethnic Study of Atherosclerosis
Susan R. Heckbert, MD, PhD*,*,
Wendy Post, MD, MS, FACC ,
Gregory D.N. Pearson, MD, PhD ,
Donna K. Arnett, PhD||,
Antoinette S. Gomes, MD¶,
Michael Jerosch-Herold, MD#,
W. Gregory Hundley, MD, FACC**,
Joao A. Lima, MD, FACC and
David A. Bluemke, MD, PhD
* Department of Epidemiology, University of Washington, Seattle, Washington
Department of Medicine, Johns Hopkins University, Baltimore, Maryland
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland
Department of Radiology, Columbia University, New York, New York
|| Department of Epidemiology, University of Alabama, Birmingham, Alabama
¶ Department of Radiology, University of California, Los Angeles, California
# Department of Radiology, University of Minnesota, Minneapolis, Minnesota
** Department of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Manuscript received January 19, 2006;
revised manuscript received March 20, 2006,
accepted March 30, 2006.
* Reprint requests and correspondence: Dr. Susan R. Heckbert, University of Washington Cardiovascular Health Research Unit, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101-1448. (Email: heckbert{at}u.washington.edu).
OBJECTIVES: The goal of this study was to examine the cross-sectional associations of cardiovascular risk factors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance imaging (MRI) in the Multiethnic Study of Atherosclerosis (MESA).
BACKGROUND: Cardiovascular risk factors including hypertension, smoking, and obesity are known to be associated with increased LV mass, but less is known about the association of risk factors with LV systolic function, particularly in populations without clinical cardiovascular disease.
METHODS: Participants were from 4 racial/ethnic groups and were free of clinical cardiovascular disease. Blood pressure, health habits, body mass index, lipid levels, and glucose abnormalities were assessed and MRI exams performed at baseline (n = 4,869). Multivariable linear regression was used to model the association of risk factors with LV mass, end-diastolic volume, stroke volume, ejection fraction, and cardiac output.
RESULTS: The mean age was 62 years, and 52% of the participants were women. After adjustment for sociodemographic variables and height, higher systolic blood pressure and body mass index were associated with larger LV mass and volumes. Current smoking and diabetes were associated with greater LV mass (+7.7 g, 95% confidence interval [CI] +5.5 to +9.9 and +3.5 g, 95% CI +1.2 to +5.8, respectively), and with lower stroke volume (–1.9 ml, 95% CI –3.3 to –0.5 and –4.5 ml, 95% CI –6.0 to –3.0, respectively) and lower ejection fraction (–1.6%, 95% CI –2.1 to –1.0 and –0.8%, 95% CI –1.5 to –0.2, respectively).
CONCLUSIONS: In this cohort free of clinical cardiovascular disease, modifiable risk factors were associated with subclinical alterations in LV size and systolic function as detected by cardiac MRI.
|
Abbreviations and Acronyms
| | CARDIA = Coronary Artery Risk Development in Young Adults | | HDL = high-density lipoprotein | | ICC = intraclass correlation coefficient | | LDL = low-density lipoprotein | | LV = left ventricular | | MESA = Multiethnic Study of Atherosclerosis | | MRI = magnetic resonance imaging |
|
This article has been cited by other articles:
|
|
|
|
 
A. Bidulescu, J. Liu, S. K. Musani, E. R. Fox, T. E. Samdarshi, D. F. Sarpong, V. Vaccarino, P. W. Wilson, D. K. Arnett, R. Din-Dzietham, et al.
Association of Adiponectin With Left Ventricular Mass in Blacks: The Jackson Heart Study
Circ Heart Fail,
November 1, 2011;
4(6):
747 - 753.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. H. Gaasch and M. R. Zile
Left Ventricular Structural Remodeling in Health and Disease: With Special Emphasis on Volume, Mass, and Geometry
J. Am. Coll. Cardiol.,
October 18, 2011;
58(17):
1733 - 1740.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. B. Turkbey, J.-Y. C. Backlund, S. Genuth, A. Jain, C. Miao, P. A. Cleary, J. M. Lachin, D. M. Nathan, R. J. van der Geest, E. Z. Soliman, et al.
Myocardial Structure, Function, and Scar in Patients With Type 1 Diabetes Mellitus
Circulation,
October 18, 2011;
124(16):
1737 - 1746.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Dibble, J. A. C. Lima, D. A. Bluemke, J. A. Chirinos, H. Chahal, M. R. Bristow, R. A. Kronmal, R. G. Barr, V. A. Ferrari, K. J. Propert, et al.
Regional Left Ventricular Systolic Function and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis Right Ventricle Study
Chest,
August 1, 2011;
140(2):
310 - 316.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Shimbo, P. Muntner, D. Mann, R. G. Barr, W. Tang, W. Post, J. Lima, G. Burke, D. Bluemke, and S. Shea
Association of Left Ventricular Hypertrophy With Incident Hypertension: The Multi-Ethnic Study of Atherosclerosis
Am. J. Epidemiol.,
April 15, 2011;
173(8):
898 - 905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. E. Ventetuolo, P. Ouyang, D. A. Bluemke, H. Tandri, R. G. Barr, E. Bagiella, A. R. Cappola, M. R. Bristow, C. Johnson, R. A. Kronmal, et al.
Sex Hormones Are Associated with Right Ventricular Structure and Function: The MESA-Right Ventricle Study
Am. J. Respir. Crit. Care Med.,
March 1, 2011;
183(5):
659 - 667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. P. Aaron, H. Tandri, R. G. Barr, W. C. Johnson, E. Bagiella, H. Chahal, A. Jain, J. R. Kizer, A. G. Bertoni, J. A. C. Lima, et al.
Physical Activity and Right Ventricular Structure and Function: The MESA-Right Ventricle Study
Am. J. Respir. Crit. Care Med.,
February 1, 2011;
183(3):
396 - 404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. Drazner
The Progression of Hypertensive Heart Disease
Circulation,
January 25, 2011;
123(3):
327 - 334.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. L. Meijs, Y. Vergouwe, M. J. M. Cramer, E.-J. A. Vonken, B. K. Velthuis, D. J. Verton, Y. v. d. Graaf, F. L. Visseren, W. P. Mali, P. A. Doevendans, et al.
A prediction model for left ventricular mass in patients at high cardiovascular risk
European Journal of Cardiovascular Prevention & Rehabilitation,
December 1, 2010;
17(6):
621 - 627.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Redline
Obstructive Sleep Apnea-Hypopnea and Incident Stroke: the Sleep Heart Health Study
Am. J. Respir. Crit. Care Med.,
November 15, 2010;
182(10):
1332 - 1333.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Cheng, V. Xanthakis, L. M. Sullivan, W. Lieb, J. Massaro, J. Aragam, E. J. Benjamin, and R. S. Vasan
Correlates of Echocardiographic Indices of Cardiac Remodeling Over the Adult Life Course: Longitudinal Observations From the Framingham Heart Study
Circulation,
August 10, 2010;
122(6):
570 - 578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Gottlieb, G. Yenokyan, A. B. Newman, G. T. O'Connor, N. M. Punjabi, S. F. Quan, S. Redline, H. E. Resnick, E. K. Tong, M. Diener-West, et al.
Prospective Study of Obstructive Sleep Apnea and Incident Coronary Heart Disease and Heart Failure: The Sleep Heart Health Study
Circulation,
July 27, 2010;
122(4):
352 - 360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Velagaleti, P. Gona, M. L. Chuang, C. J. Salton, C. S. Fox, S. J. Blease, S. B. Yeon, W. J. Manning, and C. J. O'Donnell
Relations of Insulin Resistance and Glycemic Abnormalities to Cardiovascular Magnetic Resonance Measures of Cardiac Structure and Function: The Framingham Heart Study
Circ Cardiovasc Imaging,
May 1, 2010;
3(3):
257 - 263.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. T. Yan, R. T. Yan, M. Cushman, A. Redheuil, R. P. Tracy, D. K. Arnett, B. D. Rosen, R. L. McClelland, D. A. Bluemke, and J. A.C. Lima
Relationship of interleukin-6 with regional and global left-ventricular function in asymptomatic individuals without clinical cardiovascular disease: insights from the Multi-Ethnic Study of Atherosclerosis
Eur. Heart J.,
April 1, 2010;
31(7):
875 - 882.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. Rodriguez, A. V. Diez-Roux, A. Moran, Z. Jin, R. A. Kronmal, J. Lima, S. Homma, D. A. Bluemke, and R. G. Barr
Left Ventricular Mass and Ventricular Remodeling Among Hispanic Subgroups Compared With Non-Hispanic Blacks and Whites: MESA (Multi-Ethnic Study of Atherosclerosis)
J. Am. Coll. Cardiol.,
January 19, 2010;
55(3):
234 - 242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Lieb, V. Xanthakis, L. M. Sullivan, J. Aragam, M. J. Pencina, M. G. Larson, E. J. Benjamin, and R. S. Vasan
Longitudinal Tracking of Left Ventricular Mass Over the Adult Life Course: Clinical Correlates of Short- and Long-Term Change in the Framingham Offspring Study
Circulation,
June 23, 2009;
119(24):
3085 - 3092.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Gu, V. Pandey, D. L. Geenen, S. A.K. Chowdhury, and M. R. Piano
Cigarette smoke-induced left ventricular remodelling is associated with activation of mitogen-activated protein kinases
Eur J Heart Fail,
November 1, 2008;
10(11):
1057 - 1064.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kozakova, E. Muscelli, A. Flyvbjerg, J. Frystyk, C. Morizzo, C. Palombo, and E. Ferrannini
Adiponectin and Left Ventricular Structure and Function in Healthy Adults
J. Clin. Endocrinol. Metab.,
July 1, 2008;
93(7):
2811 - 2818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Williams
The Year in Hypertension
J. Am. Coll. Cardiol.,
May 6, 2008;
51(18):
1803 - 1817.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. Abel, S. E. Litwin, and G. Sweeney
Cardiac Remodeling in Obesity
Physiol Rev,
April 1, 2008;
88(2):
389 - 419.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ravani, P. Parfrey, S. Murphy, V. Gadag, and B. Barrett
Clinical research of kidney diseases IV: standard regression models
Nephrol. Dial. Transplant.,
February 1, 2008;
23(2):
475 - 482.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ravani, P. Parfrey, V. Gadag, F. Malberti, and B. Barrett
Clinical research of kidney diseases III: Principles of regression and modelling
Nephrol. Dial. Transplant.,
December 1, 2007;
22(12):
3422 - 3430.
[Full Text]
[PDF]
|
|
|
|
