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J Am Coll Cardiol, 2006; 47:1777-1785, doi:10.1016/j.jacc.2006.02.002
(Published online 11 April 2006). © 2006 by the American College of Cardiology Foundation |
Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Seattle, Washington
Manuscript received November 4, 2005; revised manuscript received November 22, 2005, accepted December 19, 2005.
* Reprint requests and correspondence: Dr. Charles E. Murry, Director, Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, Washington 98109. (Email: murry{at}u.washington.edu).
Substantial evidence indicates that cell transplantation can improve function of the infarcted heart. A surprisingly wide range of non-myogenic cell types improves ventricular function, suggesting that benefit may result in part from mechanisms that are distinct from true myocardial regeneration. While clinical trials explore cells derived from skeletal muscle and bone marrow, basic researchers are investigating sources of new cardiomyocytes, such as resident myocardial progenitors and embryonic stem cells. In this commentary, we briefly review the evolution of cell-based cardiac repair, discuss the current state of clinical research, and offer some thoughts on how newcomers can critically evaluate this emerging field.
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