Please click here to obtain permission to reproduce this image.
Click on image to view larger version.
Figure 3 Immunohistochemical Identification of Invading SMCs (Anti- -SMC Actin) and Endothelium (Microvessels, Anti-CD34) in Late-Stage Thrombi in Plaque Ruptures (Infiltrating, 4 to 7 Days of Age) and Erosions (Healing, >7 Days of Age)
(A) Higher-power view of a late-stage infiltrating thrombus in plaque rupture (Movat pentachrome, x400). (B) Area within the inset in A shows infiltrating SMCs at the plaque/thrombus interface (-SMC actin, brownish-black reaction product, x400 magnification). (C) Similar region as B, showing numerous CD34+ microvessels within the thrombus (anti-CD34, x400 magnification). (D) Healing thrombus (>7 days in age) in plaque erosion (Movat pentachrome, x400 magnification). Note the presence of proteoglycan matrix within the deeper regions of the plaque/thrombus interface highlighted by the inset. (E) -SMC actin immunostaining showing organized layers of SMCs at the base of the thrombus (x400 magnification). (F) Similar area as in E, showing an abundance of endothelial cells with microvessels formation (anti-CD34, x400 magnification). PL = plaque substrate; other abbreviations as in Figure 1.
|
