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Figure 2 Morphology of Coronary Thrombi With Early, Late (Lytic), Infiltrating, and Healing Maturation in Plaque Erosion
(A and B) Low-power view of a human coronary "lipid pool" (LP) lesion consistent with pathological intimal thickening with a nonocclusive early thrombus (<1 day of age). (C) Corresponding higher-power view within the region of the inset in A consisting of platelets, fibrin, and intact neutrophils. (D and E) Human coronary plaque erosions with a superimposed lytic thrombus (1 to 3 days in age). (F) Higher-power view of the thrombus with degrading inflammatory cells; the inset shows evidence of nuclear degradation (x1,000 magnification). (G and H) Low-power view of a fibroatheroma with a superimposed infiltrative thrombus attributed to plaque erosion (4 to 7 days in age). (I) Corresponding higher-power view of the infiltrative thrombus with invading mesenchymal cells with the morphologic appearance of SMCs and endothelial cells. (J and K) Macrophage-rich early fibroatheroma with coronary plaque erosions and superimposed healing thrombus (>7 days of age). (L) Higher-power view of the healing thrombus composed of layers of SMCs and proteoglycan-collagen matrix. A, D, G, J: x20 magnification, H&E staining; B, E, J, K: x20 magnification, Movat Pentachrome staining; and C, F, I, L: x400 magnification, H&E staining. Abbreviations as in Figure 1.
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