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Figure 1 Heart Failure Free Survival by Adipokine Concentration
(A and B) Kaplan-Meier curves are shown for survival free of heart failure according to baseline thirds of resistin and adiponectin (log-rank p < 0.0001 for resistin, p = 0.7 for adiponectin). (C and D) Dose-response relationships between resistin and adiponectin and heart failure are illustrated with generalized additive Cox models (maximally adjusted as in Model 3E) (Table 3) using penalized splines. Dashed lines represent 95% confidence limits of the resulting hazard ratios. (E and F) Histograms illustrate the frequency distribution of study subjects across concentrations of resistin and adiponectin. There is a linear dose-response relationship of resistin with risk of heart failure across the range where the greatest number of subjects contribute information on resistin concentration.
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