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Figure 1 Effects of In Vivo Nitroglycerin Treatment and In Vitro ALDH Inhibition on Nitroglycerin Reactivity in Human Bypass Vessels
Effects of in vivo nitroglycerin (GTN) treatment and of in vitro inhibition of the vascular aldehyde dehydrogenase (ALDH) with benomyl on GTN dose–response relationship of A. mammaria (left panel) and V. saphena (right panel). In vivo GTN treatment causes a marked shift of the GTN dose–response relationship to the right compatible with tolerance. The shift was almost identical as compared with that obtained with the ALDH inhibitor benomyl, compatible with an inhibition of the enzyme in response to chronic GTN treatment. Data are mean ± SEM from 5 to 9 patients representing 9 to 13 vessel segments/group (see Table 2). *p < 0.05 of GTN or benomyl treatment versus without pretreatment. CTR = control group.
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