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Figure 1 Laboratory Assessment of Aspirin Responsiveness
Arachidonic acid (AA) stimulation of platelet aggregation depends directly on cyclooxygenase (COX)-1 activity. In vivo production of thromboxane A2 (TxA2) is assessed by measurement of stable metabolites via enzyme-linked immunoassays. Adenosine diphosphate (ADP)- and collagen-stimulated aggregation are COX-1–nonspecific methods. Aggregation occurs through COX-1–independent and –dependent pathways after stimulation by the latter agonists. ASA = acetylsalicylic acid (aspirin); GP = glycoprotein; LTA = light transmittance aggregometry; PFA = platelet function analyzer; PLA2 = phospholipase A2; PRP = platelet-rich plasma; TEG = thrombelastography.
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