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Figure 2 Abnormal Angiogenesis
Overexpression of VEGF in the MDSC-VEGF50–injected hearts formed disorganized vasculature (CD31 immunostaining, white) 12 weeks after injection. In contrast, we observed normal spatially organized vasculature in hearts transplanted with MDSCs expressing lower levels of the VEGF transgene (MDSC-VEGF25 group) or control MDSCs (MDSC-LacZ) (200x magnification). Abbreviations as in Figure 1.
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