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Figure 1 VEGF-Induced Infarct Neovascularization
Hearts in the muscle-derived stem cell (MDSC)-LacZ, MDSC-vascular endothelial growth factor (VEGF)25, and MDSC-VEGF50 groups contained the most blood vessels per high-power field (HPF) (200x magnification) in the infarct area, and significantly more than the phosphate-buffered saline (PBS)- or MDSC-FLT–injected hearts (*p < 0.01 vs. PBS;  p < 0.01 vs. MDSC-FLT). Hearts in the MDSC-FLT group displayed comparable vascularity to the control PBS-injected hearts. The MDSC-VEGF25 and MDSC-VEGF50 groups displayed higher capillary densities than the MDSC-LacZ group ( p < 0.01 vs. MDSC-LacZ). The MDSC-VEGF25 group displayed comparable vascularity to the MDSC-VEGF50 group.
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