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Figure 1 iNO Reduces Infarct Size After Ischemia-Reperfusion Injury
(Top) Evan's blue and triphenyl tetrazolium chloride staining of representative transverse midventricle sections from pigs subjected to left anterior descending coronary artery occlusion (50 min) and reperfusion (4 h) treated with saline (control), inhaled nitric oxide (iNO), or intravenous nitroglycerin (IV-NTG). The area at risk (AAR) is delineated by the absence of dark blue staining (indicated by oblique lines); viable myocardium within this region is stained red, and infarcted tissue remains white. (Bottom) Quantitative measurement of left ventricular area at risk (% LV, left) and infarct size (% of AAR, right) in control (n = 13), iNO (n = 12), and IV-NTG (n = 10) pigs; *p < 0.05 versus control.
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