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Figure 7 Effect of ASK1 Inhibition on MAPK Activation
(A) Western blot analysis for phospho- and total-c-Jun NH2-terminal kinase (JNK), p38 MAP kinase, or extracellular signal-regulated kinase (ERK) 4 weeks after gene transfer. (B to D) Densitometric analysis of blots. Ratio of phospho- and total-JNK, p38 MAPK, or ERK in a rAAV/LacZ-treated heart was expressed as 1. Blue and red bars represent rAAV/LacZ (n = 6) and rAAV/ASK N(KR) (n = 5) groups, respectively. Abbreviations as in Figure 1.
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