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Figure 5 Bar Graphs of Inflammatory Cytokine Release
Bar graphs representing changes in inflammatory cytokine release among control and prednisone- and Taxus-treated arteries 7 days following stent implantation. Semiquantification of individual cytokines was performed by densitometry analysis and expressed as pixels. Differences were considered significant following comparison with control arteries by analysis of variance with Bonferroni correction (p < 0.25). Prednisone reduced the release of interleukin (IL)-6 (p < 0.02), monocyte chemoattractant protein (MCP)-2 (p < 0.002), MCP-3 (p < 0.009), and tumor necrosis factor (TNF)-alpha (p < 0.01) significantly compared with control subjects, whereas Taxus stents led to a further significant reduction of interleukin (IL)-10 (p < 0.01), IL-13 (p < 0.003), MCP-1 (p < 0.007), and transforming growth factor (TGF)-beta (p < 0.01). *Significance between Taxus and bare-metal stents;  significance between prednisone and bare-metal stent. GRO-a = growth-related oncoprotein-alpha.
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