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Figure 5 Capillary and Collateral Growth After eNOS S1177D Transfection In Vivo
(A) Example of platelet endothelial adhesion molecule-1 staining of capillaries (red bar = 100 µm). (B) Three days after transfection, the ischemic area of endothelial nitric oxide synthase (eNOS) S1177D-transfected animals displayed increased capillary levels compared with the eNOS+ L-nitroarginine-methylester (L-NAME) group. (C) The pro-angiogenic effect was found attenuated at day 49. (D) However, the number of collaterals at day 49 (postmortem angiogram) was increased after eNOS S1177D transfection (n = 6/group).
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