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Figure 2 Detection using magnetic resonance imaging (MRI) at 1.5 T, of Feridex-labeled mesenchymal stem cells (107 to 108 cells) injected into the myocardium of a swine; MRI was performed 24 h after injection. (B) Magnification of view inside the yellow box in A (reprinted from Kraitchman et al. [15] with permission). (C) Detection using MRI at 1.5 T of micrometer-sized superparamagnetic iron oxide–labeled mesenchymal stem cells (105 cells) implanted in the myocardium of a swine (reprinted from Hill et al. [77] with permission). (D) The color map corresponds to T2* values indicated on the scale immediately to the right; T2* values of micrometer-sized superparamagnetic iron oxide–labeled cells are very close to those of lateral myocardial wall at the heart/lung boundary. Obviously, the reduction of T2* at myocardium and air interface is a source of interference for detection of cells. LV = left ventricle; RV = right ventricle.
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