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Figure 7 Hemorrhagic foci in PDGFR-ß antibody-treated infarcts. (A) After 7 days of reperfusion, immunoglobulin IgG-treated mice show a well-formed wound with significant deposition of extracellular matrix and no red blood cell extravasation. (B) The PDGFR-ß inhibition with the neutralizing antibody APB5 resulted in extensive extravasation of red blood cells in the infarct (arrows). (C) In contrast, PDGFR- inhibition with the neutralizing antibody APA5 did not induce hemorrhagic areas in the infarct. (D) Quantitative analysis of macrophage density in the infarcted myocardium. The PDGFR- and PDGFR-ß inhibition resulted in enhanced macrophage density in the infarcted myocardium (**p < 0.01 vs. IgG-treated animals). (E) In contrast, neutrophil density was low in the mature scar after 7 days of reperfusion, and not significantly different between groups (magnification 400x). Abbreviations as in Figure 5.
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