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Figure 8 (A) Representative photomicrographs of hematoxylin-eosin staining of arterial sections 28 days after carotid ligation in mice receiving naloxone (right panel) or phosphate-buffered saline (PBS) injection (left panel). Arrows indicate borders of the neointima and media. Original magnification 200x. (B) Morphometric analysis of the lumen, neointima, media, and total vascular areas. Values are mean ± SD of 5 sections in each mouse. *p < 0.05; **p < 0.01; ***p < 0.005 compared with the mice receiving PBS injection. (C) Degree of neointima formation 28 days after carotid ligation was calculated according to neointima/media area (N/M) ratio. ***p < 0.005 compared with the mice receiving PBS injection (bar = 100 µm).
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