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Figure 2 The association of dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with heart rate and prolonged QT, evaluated non-parametrically using restricted cubic splines and adjusted for other risk factors (see Table 2 footnote). For heart rate, a possible threshold effect was present at intake of 
300 mg/day, particularly after exclusion of participants taking beta-blockers (n = 656) (p threshold effect = 0.066), with steeper decline in heart rate with intakes between 0 and 300 mg/day, and then more gradual decline. A somewhat similar pattern was seen for prolonged QT, although with less evidence for departure from a linear relationship (p threshold effects >0.20). Few subjects with intakes >1.5 g/day (n = 24) limited the certainty of associations at these high levels of intake. *The p value for the continuous association over the entire range. bpm = beats/min; QTI = QT index.
