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Figure 3 (A) Representive M-mode echocardiography images of wild-type (WT) and harlequin (Hq) mice, either treated with vehicle or with EUK-8, following sham operation or 7 or 14 days after transverse aortic constriction (TAC). (B) Fractional shortening (FS), a measure of systolic contractility, was similar in sham-operated mutant and WT mice but was progressively and significantly decreased in Hq mutant mice compared with WT mice after 4 weeks of TAC. (C) The heart weight (HW)/tibial length (TL) ratios increased in untreated WT and Hq mice after 4 weeks of TAC compared with corresponding sham-operated groups, although the percentage increase was more pronounced in Hq mutant mice. The WT and Hq mice treated with EUK-8 did not demonstrate a significant increase in HW/TL ratio after TAC compared with corresponding sham groups.
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