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Figure 3 Bone marrow cells promote myocardial regeneration after infarction. The intramyocardial injection of enhanced green fluorescent protein (EGFP)-positive blood marrow cells in mice acutely after infarction induced the formation of new myocardium. In the infarcted region, the newly formed myocytes are small (A; alpha-sarcomeric actin, red) and show EGFP in the cytoplasm (B, green). (C) This merged image of A and B. The regenerated myocytes express both -sarcomeric actin and EGFP (yellow-green). These myocytes are 400 µm3 in volume and, because of their size, cannot be the product of cell fusion. Nuclei are labeled by propidium iodide (blue). *Spared myocytes in the subendocardium. EP = epicardium; EN = endocardium.
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