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Figure 6 Expression of ACVI in AV node. (A) 10x images of AV node region in heart from a mouse with cardiac-directed expression of ACVI. Green indicates staining for Cx45, a marker for AV nodal tissue; red indicates ACV/VI protein; overlap image (right) indicates co-expression of Cx45 and ACV/VI. (B) 60x images of area contained in white box in (A). There is considerable co-localization of Cx45 AV nodal stain with ACV/VI. (C) 60x image of ACVI and transgene-negative sibling mouse (control); heart sections exposed to ACV/VI antibodies show increased ACVI expression compared to heart sections from transgene-negative sibling. White bar lengths are (A) 100 µm; (B) 20 µm; (C) 20 µm. Abbreviations as in Figures 2 and 3.
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