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Figure 5 Midostaurin increases eNOS protein expression in the aorta of SHR. Six SHR were treated orally with vehicle (SHR) and six other SHR with midostaurin (SHR+Mido, 75 mg/kg/day) for 5 days. Endothelial nitric oxide synthase was stained immunohistochemically with an anti-eNOS monoclonal antibody. In the negative control, mouse immunoglobulin G was used instead of the anti-eNOS antibody. Micrographs are shown in 400x magnification. Abbreviations as in Figure 1.
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