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Figure 2 Effect of V2 antagonism on solute-free water excretion. The top panel presents data after single-blind placebo administration (baseline). The bottom panel depicts results after administration of double-blind study medication, consisting of either placebo or one of six doses of lixivaptan as indicated. Lixivaptan dramatically increased free water excretion within the first 2 h, after study drug administration. See text for specific p values.
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