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Figure 1 Schematic representation of the coronary artery patency status of 12 dogs during two sequential observation periods. All dogs were observed during an initial 60-min period (period 1). During the second period (period 2), six animals received sildenafil (50 µg/kg bolus followed by 4 µg/kg/min), whereas six control animals received no further treatment. White areas represent coronary patency (flow >25% of baseline), and black areas represent occlusion.
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