LETTERS TO THE EDITOR
Drug-eluting stent thrombosis: Results from a pooled analysis including 10 randomized studies.REPLY
Raúl Moreno, MD, FESC*,
Cristina Fernández, MD and
Carlos Macaya, MD, FESC
* Interventional Cardiology, Hospital Clinico San Carlos, Mart& acute;n Lagos, s/n, 28040 Madrid, Spain (Email: raulmorenog{at}terra.es).
We thank Dr. Kaneda for his interest in our study. We agree
with the affirmation that the mean stented length for each study may not necessarily
represent the stent length of the actual cases of stent thrombosis. Because of that, as we
described in the Methods section (Statistical Analysis), we contacted the principal
investigators of all studies in which at least one drug-eluting stent thrombosis was
documented, requesting the total stent length for each of these cases (1). As we
already reported in our study, the mean stented length for cases with drug-eluting
stent thrombosis was 23.4 mm, which was significantly longer than that in those patients
not suffering stent thrombosis (21.3 mm), thus confirming that the total stented length is
related to the risk of thrombosis after drug-eluting stent implantation.
Moreover, our data are consistent with other studies that have also shown a
significant relationship between stent length and the risk of stent thrombosis, both with
bare-metal (2) and drug-eluting stents (3,4).
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References
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1. Moreno R, Fernandez C, Hernandez R, et al. Drug-eluting stent thrombosisResults from a pooled analysis including 10 randomized studies. J Am Coll Cardiol 2005;45:954-959.[Abstract/Free Full Text]2. Cutlip DE, Baim DS, Ho KKL, et al. Stent thrombosis in the modern eraA pooled analysis of multicenter coronary stent clinical trials. Circulation 2001;103:1967-1971.[Abstract/Free Full Text] 3. Chieffo A, Bonizzoni E, Orlic D, et al. Intraprocedural stent thrombosis during implantation of sirolimus-eluting stents Circulation 2004;109:2732-2736.[Abstract/Free Full Text] 4. Iakovou I, Schmidt T, Bonizzoni E, et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents JAMA 2005;293:2126-2130.[Abstract/Free Full Text]
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