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Figure 4 Tissue hypoxia in the arterial wall. (A) Hypoxia-inducible factor (HIF)-1 alpha expression was increased at all time points after stenting (upper panel). (B) Pimonidazole adducts were identified at all time points after stenting (upper panel). Protein loading was assessed by Ponceau-red staining (lower panel of A and B). (C) Immunohistochemistry showing pimonidazole adducts (stained brown) at the media/adventitia border at 1 week after stenting. Isch-m = ischemic muscle + pimonidazole; UI = uninjured artery; UI-P = uninjured + pimonidazole.
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