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Figure 1 Endothelial function and plasma nitric oxide species are decreased in individuals with increasing numbers of cardiovascular risk factors. (A) Flow-mediated dilation (FMD) and (B) percentage of FMD compared to glycerol trinitrate (GTN)-induced dilation of brachial artery (FMD/GTN ratio) are significantly lower in individuals with cardiovascular risk factors. (C) Nitros(yl)ated species (RXNO) in plasma, representing the circulating pool of bioactive nitric oxide, are also significantly attenuated with increasing numbers of risk factors. Columns = mean values; error bars = SE. P values are Bonferroni-corrected for 10 pairwise comparisons.
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