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Figure 1 (A) Concentrations of soluble plasma tissue factor (pTF) (filled bars) and MCP-1 (open bars) in plasma harvested before cardiopulmonary bypass (CPB) (Pre) and simultaneously from the perfusion circuit (Perf) and pericardial wound (Wnd) during CPB. Values are means ± SEM, n = 7. p = 0.0002 and 0.0009 for Wnd pTF versus Pre pTF and Perf pTF, respectively. p = 0.000017 and 0.0000093 for Wnd MCP-1 versus Pre MCP-1 and Perf MCP-1, respectively. p = 0.18 for Pre pTF versus Perf pTF and for Pre MCP-1 versus Perf MCP-1. (B) Wound pTF with C5a-stimulated mononuclear cells (2 x 106/ml) from all locations (open bars) and unstimulated wound mononuclear cells (filled bars) convert all available factor VII (fVII) to fVIIa. Unstimulated monocytes from pre-bypass and perfusate samples partially activate fVII. Values are means ± SEM, n = 6.
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