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Figure 3 A High-Dose Patient, Further Example and Quadrant Analysis Approach
T2*-weighted imaging of a right common carotid artery before and after ultrasmall superparamagnetic iron oxide (USPIO) infusion at the 2 time points of (A and B) 0 and (C and D) 12 weeks. (B) USPIO uptake can clearly be seen in the plaque at baseline (yellow arrowheads). (C) Sinerem has been cycled out of the plaque before reinfusion at 12 weeks (red arrowheads). (D) The plaque enhances at 12 weeks (blue arrowheads), indicating that the high-dose statin treatment has damped the USPIO-defined inflammation. Plaque segmentation was performed using a combination of multicontrast sequences. The cross hairs centered through the middle of the lumen divide the vessel into quadrants. Signal from artifact, extravascular structures, and the luminal blood pool (green asterisks) are excluded from the analysis.
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