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Figure 2 Example of a High-Dose Patient
T2*-weighted imaging of a left common carotid artery before and after ultrasmall superparamagnetic iron oxide (USPIO) infusion at the 3 time points of (A and B) 0, (C and D) 6, and (E and F) 12 weeks. (B) USPIO uptake can clearly be seen in the plaque at baseline (yellow arrowhead). (C and E) Pre-USPIO imaging remains very similar at all 3 time points with Sinerem having been cycled out of the plaque before reimaging (red arrowhead). (D) The plaque begins to enhance at 6 weeks (blue arrowhead). This signifies that there is a predominant T1 effect, indicating minimal USPIO uptake and a lack of activated macrophages (minimal inflammation). (E) No residual USPIO signal is also seen in the pre-USPIO imaging at 12 weeks, and (F) signal enhancement post-USPIO can be seen with no evidence of signal voids (blue arrowheads).
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