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Figure 4 Intravascular OFF-Resonance Enhancement After MION-47 Administration
Conventional T1-weighted magnetic resonance angiography (MRA) in a Watanabe rabbit at baseline (A), on day 0 (B), on day 1 (C), and on day 6 (D) after the injection of superparamagnetic nanoparticles are shown. Injection of the contrast agent resulted in decreased intravascular signal, due to T2*-shortening of the blood. Using inversion recovery with ON-resonant water suppression (IRON), blood, fat, and muscle were homogenously suppressed at baseline (E). Monocrystalline iron-oxide nanoparticle (MION) 47 injection contributed to strong intravascular OFF-resonance enhancement on day 0 (F) and day 1 (G), which approached baseline at later times (H and I), allowing for better judgment of the aortic wall.
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