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Figure 2 Histology of Hyperlipidemic Versus Control Rabbits
Watanabe rabbits exhibited lipid-rich plaque formation (A) with a high density of macrophages (acid phosphatase staining in panel B). The high density of macrophages in the atherosclerotic plaque could be confirmed by RAM-11 immunostaining (macrophages stained green by RAM-11 and cell nuclei stained blue by 4',6-diamidino-2-phenylindole-dihydrochloride [DAPI], panels C and D). No plaque formation was observed in control rabbits (E to H).
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