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Figure 7 AAMP Blockade Reduces Wire-Induced NI Formation and SMC Density in ApoE–/– Mice
(A) Mice intraperitoneally treated with nonimmune serum developed normal neointimal hyperplasia, whereas in the anti-rAAMP-ab–treated group, neointimal area was significantly reduced. (B) Histomorphometrical assessment revealed a marked reduction of neointimal hyperplasia in the anti-rAAMP-ab–treated group, whereas medial areas did not differ. (C and D) One week after anti-rAAMP-ab treatment, neointimal SMC density represented by  -SMA staining was reduced compared with control. After 4 weeks, anti-rAAMP-ab treatment did not reduce neointimal SMC density compared with nonimmune serum. (E) Vascular cell proliferation analysis revealed similar proliferation indexes (percent Ki67-positive nuclei) in the neointima (NI) at 1 and 4 weeks after injury in both groups. Abbreviations as in Figures 2 and 6.
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