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Figure 3 Plaque With Grade 2 Contrast-Agent Enhancement Showing Abundant Neovascularization at Histology
Panel A shows 3 consecutive frames of contrast-enhanced ultrasound imaging of an atherosclerotic lesion in the carotid bulb, showing contrast microbubbles within the plaque (grade 2 contrast-agent enhancement). Micrograph in panel B shows a carotid hemorrhagic fibrocalcific plaque with an eccentric large necrotic core occupying approximately 60% of the plaque area (Movat's pentachrome staining, x0.5). In the area of a thin fibrous cap (C, which represents the inset in B) nearby the atheroma, numerous CD31/CD34 positive neovessels are present. It is worth noting the presence of a large first-order vasa vasorum (*) with a thin vessel wall surrounded by small second-order vasa (arrows, x10).
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