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Figure 1 Survival Rates and Echocardiographic Assessment
(A) Survival rates over 6 weeks after cell transplantation in the animals injected with human muscle derived cells or control phosphate-buffered saline (PBS) (Kaplan-Meier survival curve, p = 0.13). (B) Echocardiography performed 2 and 6 weeks after cell transplantation demonstrated smaller left ventricular areas in end-diastole of hearts injected with CD56+CD34+CD144+ cells when compared with those in the other groups (baseline: data from NOD/SCID mice without infarction and cellular injection). (C) The CD56+CD34+CD144+ myoendothelial cell group also displayed greater left ventricular contractility, as measured by fractional area change, when compared with that in the other groups at both the 2 and 6 weeks time points ( p < 0.05, CD56+CD34+CD144+ cells vs. CD56+CD34–CD144– cells and PBS). (D) No difference in left ventricular end-diastolic areas was observed between hearts injected with unsorted myoblasts and hearts injected with myogenic CD56+ sorted cells 2 weeks after cell transplantation. (E) The unsorted group also displayed a similar level of left ventricular contractility, as measured by fractional area change, as the CD56+ cell group.
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